| MP:0001261 | obese | "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0002953 | thick ventricular wall | "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0003333 | liver fibrosis | "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0010580 | decreased heart left ventricle size | "less than average size of the left ventricle compared to the average for a particular population" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0010724 | thick interventricular septum | "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0010959 | abnormal oxidative phosphorylation | "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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| MP:0011635 | abnormal mitochondrial crista morphology | "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061] |
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Allelic Composition: Manftm1c(KOMP)Wtsi/Manftm1c(KOMP)Wtsi
Genetic Background: involves: C57BL/6N * FVB/N
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