| MP:0000734 | muscle hypoplasia | "underdevelopment or atrophy of muscle" [J:15108] |
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Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Nrcamm1J/Nrcamm1J,Sh3tc2m1J/Sh3tc2m1J
Genetic Background: B6.Cg-Nrcamm1J Sh3tc2m1J/GrsrRwb
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| MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei
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| MP:0000940 | abnormal motor neuron innervation | "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Pax7tm1Pgr/Pax7+,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
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| MP:0000965 | abnormal sensory neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0001052 | abnormal muscle innervation | "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei
Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N
Allelic Composition: GarsC201R/GarsGt(XM256)6Byg,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsC201R,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsNmf249
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J
Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA
Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/Gars+,Scn8am10J/Scn8a+
Genetic Background: involves: BALB/cAnN * C3H/HeJ * FVB/NJ
Allelic Composition: GarsNmf249/Gars+,Scn8am10J/Scn8a+
Genetic Background: involves: C57BL/6J * FVB/NJ
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: GarsC201R/GarsC201R
Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei
Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N
Allelic Composition: GarsC201R/GarsGt(XM256)6Byg,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsC201R,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsNmf249
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0001524 | impaired limb coordination | "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123] |
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Allelic Composition: GarsC201R/GarsC201R
Genetic Background: involves: BALB/cAnN * C3H/HeH
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: GarsC201R/GarsGt(XM256)6Byg,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: GarsGt(XM256)6Byg/GarsGt(XM256)6Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0002651 | abnormal sciatic nerve | "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
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| MP:0002913 | abnormal PNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J
Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA
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| MP:0002914 | abnormal endplate potential activity | "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J
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| MP:0003083 | abnormal tibialis anterior morphology | "anomaly in the the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: GarsC201R/GarsC201R
Genetic Background: involves: BALB/cAnN * C3H/HeH
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| MP:0003632 | abnormal nervous system morphology | |
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Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei
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| MP:0003635 | abnormal synaptic transmission | "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J
Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA
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| MP:0004232 | decreased muscle weight | "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0005403 | abnormal nerve conduction | "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei
Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N
Allelic Composition: GarsC201R/GarsC201R,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsNmf249
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/GarsNmf249,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0005405 | axon degeneration | "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Il4tm2Rao/Il4+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0008814 | reduced nerve conduction velocity | "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsNmf249/Gars+
Genetic Background: involves: C57BL/6J * CAST/Ei
Allelic Composition: GarsNmf249/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: C57BL/6J * CAST/Ei * FVB/N
Allelic Composition: GarsC201R/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsGt(XM256)6Byg,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/GarsC201R,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsC201R/Gars+,Nrcamm1J/Nrcamm1J
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/Gars+,Scn8am10J/Scn8a+
Genetic Background: involves: BALB/cAnN * C3H/HeJ * FVB/NJ
Allelic Composition: GarsNmf249/Gars+,Scn8am10J/Scn8a+
Genetic Background: involves: C57BL/6J * FVB/NJ
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| MP:0009406 | decreased skeletal muscle fiber number | "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0009417 | skeletal muscle atrophy | "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: GarsNmf249/Gars+,Scn8am10J/Scn8a+
Genetic Background: involves: C57BL/6J * FVB/NJ
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| MP:0009428 | decreased tibialis anterior weight | "redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
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| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: H2afxtm1Nus/H2afxtm2.1Fwa,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N
Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/Gars+,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
Allelic Composition: GarsNmf249/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: C57BL/6J * CAST/Ei * CBA/J
Allelic Composition: GarsC201R/Gars+,Tg(Thy1-YFP)16Jrs/?
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * CBA
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/GarsC201R
Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: GarsC201R/GarsC201R,Tg(CAG-GARS)DRwb/0
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J * FVB/N
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Lpltm1Ijg/Lpltm1Ijg,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: FVB/N
Allelic Composition: GarsGt(XM256)6Byg/GarsGt(XM256)6Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: GarsC201R/Gars+
Genetic Background: involves: BALB/cAnN * C3H/HeH * C57BL/6J
Allelic Composition: GarsC201R/GarsC201R
Genetic Background: involves: BALB/cAnN * C3H/HeH
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