ENSMUSG00000029821


Mus musculus

Features
Gene ID: ENSMUSG00000029821
  
Biological name :Gsdme
  
Synonyms : Gasdermin-E Gasdermin-E, N-terminal Gasdermin-E, C-terminal / Gsdme / Q9Z2D3
  
Possible biological names infered from orthology : gasdermin E / O60443
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.3
Gene start: 50188888
Gene end: 50263862
  
Corresponding Affymetrix probe sets: 10544644 (MoGene1.0st)   10544648 (MoGene1.0st)   1417903_at (Mouse Genome 430 2.0 Array)   1421534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098952
Ensembl peptide - ENSMUSP00000132062
Ensembl peptide - ENSMUSP00000130522
Ensembl peptide - ENSMUSP00000126759
Ensembl peptide - ENSMUSP00000031845
NCBI entrez gene - 54722     See in Manteia.
MGI - MGI:1889850
RefSeq - XM_011241414
RefSeq - NM_018769
RefSeq - XM_006506402
RefSeq Peptide - NP_061239
swissprot - E9Q5V3
swissprot - Q9Z2D3
swissprot - D3YYP5
swissprot - E9Q308
Ensembl - ENSMUSG00000029821
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gsdmeaENSDARG00000086762Danio rerio
 gsdmebENSDARG00000040485Danio rerio
 DFNA5ENSGALG00000010997Gallus gallus
 GSDMEENSG00000105928Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pjvk / Q0ZLH2 / Pejvakin / Q0ZLH3*ENSMUSG0000007526721


Protein motifs (from Interpro)
Interpro ID Name
 IPR007677  Gasdermin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0008219 cell death ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0060113 inner ear receptor cell differentiation IMP
 biological_processGO:0070265 necrotic cell death ISO
 biological_processGO:0070269 pyroptosis ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0098586 cellular response to virus ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:1901612 cardiolipin binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Irx4tm1Jse/Irx4+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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