ENSMUSG00000029864


Mus musculus

Features
Gene ID: ENSMUSG00000029864
  
Biological name :Gstk1
  
Synonyms : Glutathione S-transferase kappa 1 / Gstk1 / Q9DCM2
  
Possible biological names infered from orthology : Q9Y2Q3
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.1
Gene start: 42245935
Gene end: 42250447
  
Corresponding Affymetrix probe sets: 10537712 (MoGene1.0st)   1452823_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145070
Ensembl peptide - ENSMUSP00000031897
NCBI entrez gene - 76263     See in Manteia.
MGI - MGI:1923513
RefSeq - NM_029555
RefSeq Peptide - NP_083831
swissprot - A0A0N4SVE5
swissprot - Q9DCM2
Ensembl - ENSMUSG00000029864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR854927.4ENSDARG00000110055Danio rerio
 gstk1ENSDARG00000056510Danio rerio
 gstk2ENSDARG00000019585Danio rerio
 gstk4ENSDARG00000092052Danio rerio
 gstk4ENSDARG00000093119Danio rerio
 GSTK1ENSGALG00000014708Gallus gallus
 GSTK1ENSG00000197448Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001853  DSBA-like thioredoxin domain
 IPR014440  HCCA isomerase/glutathione S-transferase kappa
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IDA
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005777 peroxisome IEA
 molecular_functionGO:0004364 glutathione transferase activity ISO
 molecular_functionGO:0004602 glutathione peroxidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0002959 increased microalbumin excretion "greater than the normal amount of fragments of this protein voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0009552 urinary bladder obstruction "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0009646 urinary bladder inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

 MP:0011763 urethritis "local accumulation of fluid, plasma proteins, and leukocytes in the urethra, usually caused by an infection" [MGI:anna]
Show

Allelic Composition: Osr1tm1Jian/Osr1tm1Jian
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029864 Gstk1 / Q9DCM2 / Glutathione S-transferase kappa 1 / Q9Y2Q3*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr