ENSMUSG00000029919


Mus musculus

Features
Gene ID: ENSMUSG00000029919
  
Biological name :Hpgds
  
Synonyms : Hematopoietic prostaglandin D synthase / Hpgds / Q9JHF7
  
Possible biological names infered from orthology : O60760
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 65117293
Gene end: 65144908
  
Corresponding Affymetrix probe sets: 10545101 (MoGene1.0st)   1421492_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031982
NCBI entrez gene - 54486     See in Manteia.
MGI - MGI:1859384
RefSeq - NM_019455
RefSeq - XM_006506398
RefSeq Peptide - NP_062328
swissprot - Q9JHF7
Ensembl - ENSMUSG00000029919
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HPGDSENSGALG00000010402Gallus gallus
 HPGDSENSG00000163106Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gsta4 / P24472 / Glutathione S-transferase A4 ENSMUSG0000003234826
Gsta2 / P10648 / Glutathione S-transferase A2 / GSTA5* / GSTA3* / GSTA1* / Q7RTV2* / P08263* / P09210* / Q16772* / glutathione S-transferase alpha 1* / glutathione S-transferase alpha 5* /...ENSMUSG0000005793325
Gm3776 / predicted gene 3776 / GSTA2* / GSTA1* / GSTA3* / GSTA5* / P09210* / Q16772* / Q7RTV2* / P08263* / glutathione S-transferase alpha 1* / glutathione S-transferase alpha 5* / glutathi...ENSMUSG0000011170924
Gsta1 / P13745 / Glutathione S-transferase A1 Glutathione S-transferase A1, N-terminally processed / GSTA2* / GSTA3* / GSTA5* / P09210* / Q16772* / Q7RTV2* / P08263* / glutathione S-transfe...ENSMUSG0000007418324
Gm10639 / GSTA2* / GSTA1* / GSTA3* / GSTA5* / P09210* / Q16772* / Q7RTV2* / P08263* / glutathione S-transferase alpha 2* / glutathione S-transferase alpha 1* / glutathione S-transferase alp...ENSMUSG0000007417924
Gsta3 / P30115 / Glutathione S-transferase A3 ENSMUSG0000002593423


Protein motifs (from Interpro)
Interpro ID Name
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:2000255 negative regulation of male germ cell proliferation IGI
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004364 glutathione transferase activity ISO
 molecular_functionGO:0004667 prostaglandin-D synthase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Galctwi/Galctwi,Hpgdstm1Urad/Hpgdstm1Urad
Genetic Background: B6.Cg-Hpgdstm1Urad Galctwi

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dync2h1lln/Dync2h1lln,Ptch1tm1Mps/Ptch1tm1Mps
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Hpgdstm1Urad/Hpgdstm1Urad
Genetic Background: B6.Cg-Hpgdstm1Urad Galctwi

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Ptgdstm1Ohy/Ptgdstm1Ohy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: ApcMin/Apc+,Hpgdstm1Urad/Hpgdstm1Urad
Genetic Background: involves: 129 * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Hpgdstm1Urad/Hpgdstm1Urad
Genetic Background: B6.Cg-Hpgdstm1Urad Galctwi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029919 Hpgds / Q9JHF7 / Hematopoietic prostaglandin D synthase / O60760*  / complex






 

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