ENSMUSG00000030189


Mus musculus

Features
Gene ID: ENSMUSG00000030189
  
Biological name :Ybx3
  
Synonyms : Q9JKB3 / Y box protein 3 / Ybx3
  
Possible biological names infered from orthology : P16989 / Y-box binding protein 3
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 131364855
Gene end: 131388476
  
Corresponding Affymetrix probe sets: 10548585 (MoGene1.0st)   1435800_a_at (Mouse Genome 430 2.0 Array)   1451012_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032309
Ensembl peptide - ENSMUSP00000085172
NCBI entrez gene - 56449     See in Manteia.
MGI - MGI:2137670
RefSeq - NM_011733
RefSeq - NM_139117
RefSeq Peptide - NP_035863
RefSeq Peptide - NP_620817
swissprot - Q9JKB3
Ensembl - ENSMUSG00000030189
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YBX3ENSGALG00000031890Gallus gallus
 YBX3ENSG00000060138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ybx1 / P62960 / Y box protein 1 / P67809* / Y-box binding protein 1*ENSMUSG0000002863952
Ybx2 / Y box protein 2 / Q9Y2T7* / Y-box binding protein 2*ENSMUSG0000001855447


Protein motifs (from Interpro)
Interpro ID Name
 IPR002059  Cold-shock protein, DNA-binding
 IPR011129  Cold shock domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR019844  Cold-shock conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046622 positive regulation of organ growth IMP
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IDA
 biological_processGO:0060546 negative regulation of necroptotic process ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071474 cellular hyperosmotic response ISO
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005921 gap junction ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ybx3tm1Ley/Ybx3+,Ybx1tm1Ley/Ybx1tm1Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ybx3tm1Ley/Ybx3+,Ybx1tm1Ley/Ybx1tm1Ley
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Otx1tm1Sia/Otx1+,Otx2tm2(Otx1)Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr