ENSG00000060138


Homo sapiens

Features
Gene ID: ENSG00000060138
  
Biological name :YBX3
  
Synonyms : P16989 / Y-box binding protein 3 / YBX3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.2
Gene start: 10699089
Gene end: 10723312
  
Corresponding Affymetrix probe sets: 201160_s_at (Human Genome U133 Plus 2.0 Array)   201161_s_at (Human Genome U133 Plus 2.0 Array)   213319_s_at (Human Genome U133 Plus 2.0 Array)   228634_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000228251
Ensembl peptide - ENSP00000485718
Ensembl peptide - ENSP00000279550
NCBI entrez gene - 8531     See in Manteia.
OMIM - 603437
RefSeq - XM_017020123
RefSeq - NM_001145426
RefSeq - NM_003651
RefSeq - XM_011520871
RefSeq - XM_017020122
RefSeq Peptide - NP_001138898
RefSeq Peptide - NP_003642
swissprot - A0A0D9SEI8
swissprot - A0A024RAV4
swissprot - P16989
swissprot - A0A024RAQ1
Ensembl - ENSG00000060138
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YBX3ENSGALG00000031890Gallus gallus
 Ybx3ENSMUSG00000030189Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YBX1 / P67809 / Y-box binding protein 1ENSG0000006597851
YBX2 / Q9Y2T7 / Y-box binding protein 2ENSG0000000604744


Protein motifs (from Interpro)
Interpro ID Name
 IPR002059  Cold-shock protein, DNA-binding
 IPR011129  Cold shock domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR019844  Cold-shock conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009409 response to cold TAS
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0046622 positive regulation of organ growth IEA
 biological_processGO:0048642 negative regulation of skeletal muscle tissue development IEA
 biological_processGO:0060546 negative regulation of necroptotic process IMP
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IC
 biological_processGO:0071356 cellular response to tumor necrosis factor IMP
 biological_processGO:0071474 cellular hyperosmotic response IMP
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
 biological_processGO:2000767 positive regulation of cytoplasmic translation ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding TAS
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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