ENSG00000065978


Homo sapiens

Features
Gene ID: ENSG00000065978
  
Biological name :YBX1
  
Synonyms : P67809 / Y-box binding protein 1 / YBX1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 42682427
Gene end: 42702349
  
Corresponding Affymetrix probe sets: 208627_s_at (Human Genome U133 Plus 2.0 Array)   208628_s_at (Human Genome U133 Plus 2.0 Array)   216940_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389639
Ensembl peptide - ENSP00000405937
Ensembl peptide - ENSP00000361626
NCBI entrez gene - 4904     See in Manteia.
OMIM - 154030
RefSeq - NM_004559
RefSeq Peptide - NP_004550
swissprot - C9J5V9
swissprot - H0Y449
swissprot - P67809
Ensembl - ENSG00000065978
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ybx1ENSDARG00000004757Danio rerio
 YBX1ENSGALG00000004848Gallus gallus
 Ybx1ENSMUSG00000028639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YBX3 / P16989 / Y-box binding protein 3ENSG0000006013858
YBX2 / Q9Y2T7 / Y-box binding protein 2ENSG0000000604745


Protein motifs (from Interpro)
Interpro ID Name
 IPR002059  Cold-shock protein, DNA-binding
 IPR011129  Cold shock domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR019844  Cold-shock conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007219 Notch signaling pathway TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0035333 Notch receptor processing, ligand-dependent TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051154 negative regulation of striated muscle cell differentiation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0070934 CRD-mediated mRNA stabilization IMP
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005689 U12-type spliceosomal complex IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070937 CRD-mediated mRNA stability complex IDA
 cellular_componentGO:0071204 histone pre-mRNA 3"end processing complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding TAS
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Noncanonical activation of NOTCH3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000074181 NOTCH3 / Q9UM47  / reaction / complex






 

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