ENSMUSG00000030447


Mus musculus

Features
Gene ID: ENSMUSG00000030447
  
Biological name :Cyfip1
  
Synonyms : Cyfip1 / Cytoplasmic FMR1-interacting protein 1 / Q7TMB8
  
Possible biological names infered from orthology : Q7L576
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B5
Gene start: 55841745
Gene end: 55932602
  
Corresponding Affymetrix probe sets: 10553598 (MoGene1.0st)   1416329_at (Mouse Genome 430 2.0 Array)   1457134_at (Mouse Genome 430 2.0 Array)   1459866_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134509
Ensembl peptide - ENSMUSP00000146194
Ensembl peptide - ENSMUSP00000032629
Ensembl peptide - ENSMUSP00000082353
Ensembl peptide - ENSMUSP00000127717
NCBI entrez gene - 20430     See in Manteia.
MGI - MGI:1338801
RefSeq - XM_006540729
RefSeq - NM_001164661
RefSeq - NM_001164662
RefSeq - NM_011370
RefSeq Peptide - NP_001158134
RefSeq Peptide - NP_001158133
RefSeq Peptide - NP_035500
swissprot - Q7TMB8
swissprot - G3UZI5
swissprot - A0A0U1RQ05
swissprot - A0A0R4J119
Ensembl - ENSMUSG00000030447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyfip1ENSDARG00000044345Danio rerio
 CYFIP1ENSGALG00000016736Gallus gallus
 CYFIP1ENSG00000273749Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyfip2 / Q5SQX6 / Cytoplasmic FMR1-interacting protein 2 / Q96F07*ENSMUSG0000002034087


Protein motifs (from Interpro)
Interpro ID Name
 IPR008081  Cytoplasmic FMR1-interacting
 IPR009828  Protein of unknown function DUF1394


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016601 Rac protein signal transduction ISO
 biological_processGO:0030032 lamellipodium assembly IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0031529 ruffle organization ISS
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0048675 axon extension ISO
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050890 cognition ISO
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0097484 dendrite extension IMP
 biological_processGO:0099563 modification of synaptic structure IMP
 biological_processGO:1900006 positive regulation of dendrite development IEA
 biological_processGO:1900029 positive regulation of ruffle assembly IEA
 biological_processGO:1903422 negative regulation of synaptic vesicle recycling IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation ISO
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031209 SCAR complex ISO
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0060076 excitatory synapse IEA
 cellular_componentGO:0090724 central region of growth cone IEA
 cellular_componentGO:0090725 peripheral region of growth cone IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005522 profilin binding TAS
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0048365 Rac GTPase binding ISS
 molecular_functionGO:0051015 actin filament binding ISS


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003400 kinked neural tube "twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Nell1l7R6-8R/Nell1l7R6-8R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1l7Rl1-2R/Cyfip1l7Rl1-2R
Genetic Background: Mixed stock

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr