ENSMUSG00000020340


Mus musculus

Features
Gene ID: ENSMUSG00000020340
  
Biological name :Cyfip2
  
Synonyms : Cyfip2 / Cytoplasmic FMR1-interacting protein 2 / Q5SQX6
  
Possible biological names infered from orthology : Q96F07
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.1
Gene start: 46193850
Gene end: 46312859
  
Corresponding Affymetrix probe sets: 10385391 (MoGene1.0st)   1428347_at (Mouse Genome 430 2.0 Array)   1442167_at (Mouse Genome 430 2.0 Array)   1449273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116715
Ensembl peptide - ENSMUSP00000090853
Ensembl peptide - ENSMUSP00000090854
Ensembl peptide - ENSMUSP00000119801
Ensembl peptide - ENSMUSP00000127586
NCBI entrez gene - 76884     See in Manteia.
MGI - MGI:1924134
RefSeq - XM_006534463
RefSeq - NM_001252459
RefSeq - NM_001252460
RefSeq - NM_133769
RefSeq - XM_006534461
RefSeq - XM_006534462
RefSeq Peptide - NP_001239389
RefSeq Peptide - NP_598530
RefSeq Peptide - NP_001239388
swissprot - F7C3H9
swissprot - Q5SQX6
swissprot - F6QD74
Ensembl - ENSMUSG00000020340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyfip2ENSDARG00000036375Danio rerio
 CYFIP2ENSGALG00000003818Gallus gallus
 CYFIP2ENSG00000055163Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyfip1 / Q7TMB8 / Cytoplasmic FMR1-interacting protein 1 / Q7L576*ENSMUSG0000003044787


Protein motifs (from Interpro)
Interpro ID Name
 IPR008081  Cytoplasmic FMR1-interacting
 IPR009828  Protein of unknown function DUF1394


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0045862 positive regulation of proteolysis ISO
 biological_processGO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity ISO
 biological_processGO:0097484 dendrite extension IMP
 biological_processGO:0098609 cell-cell adhesion ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Gabra1tm1.1Mjga/Gabra1+
Genetic Background: B6J.Cg-Gabra1tm1.1Mjga

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gabra1tm1.1Mjga/Gabra1+
Genetic Background: B6J.Cg-Gabra1tm1.1Mjga

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Gabra1tm1.1Mjga/Gabra1+
Genetic Background: B6J.Cg-Gabra1tm1.1Mjga

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0003584 bifid ureter "cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra1tm1.1Mjga/Gabra1+
Genetic Background: B6J.Cg-Gabra1tm1.1Mjga

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

Allelic Composition: Cyfip2M1N/Cyfip2+
Genetic Background: (C57BL/6N x C57BL/6J)F1

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+
Genetic Background: involves: C57BL/6J * C57BL/6NTac

Allelic Composition: Cyfip2tm1(KOMP)Vlcg/Cyfip2+,Fmr1tm1Cgr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0010490 abnormal inferior vena cava valve morphology "any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gabra1tm1.1Mjga/Gabra1+
Genetic Background: B6J.Cg-Gabra1tm1.1Mjga

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Prkntm1Shn/Prkntm1Shn,Park7tm1Shn/Park7tm1Shn
Genetic Background: B6.Cg-Park7tm1Shn Prkntm1Shn

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
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Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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