ENSMUSG00000030471


Mus musculus

Features
Gene ID: ENSMUSG00000030471
  
Biological name :Zdhhc13
  
Synonyms : Q9CWU2 / Zdhhc13 / zinc finger, DHHC domain containing 13
  
Possible biological names infered from orthology : Q8IUH4 / zinc finger DHHC-type containing 13
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B4
Gene start: 48789003
Gene end: 48827440
  
Corresponding Affymetrix probe sets: 10553336 (MoGene1.0st)   1428307_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112498
Ensembl peptide - ENSMUSP00000123603
NCBI entrez gene - 243983     See in Manteia.
MGI - MGI:1919227
RefSeq - XM_006540898
RefSeq - NM_028031
RefSeq - XM_006540896
RefSeq Peptide - NP_082307
swissprot - Q9CWU2
swissprot - D3YY07
Ensembl - ENSMUSG00000030471
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zdhhc13ENSDARG00000101144Danio rerio
 ZDHHC13ENSGALG00000004085Gallus gallus
 Q8IUH4ENSG00000177054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80TN5 / Zdhhc17 / zinc finger, DHHC domain containing 17 / Q8IUH5* / zinc finger DHHC-type containing 17*ENSMUSG0000003579846
Q8VC90 / Zdhhc12 / zinc finger, DHHC domain containing 12 / Q96GR4* / zinc finger DHHC-type containing 12*ENSMUSG0000001533512


Protein motifs (from Interpro)
Interpro ID Name
 IPR001594  Palmitoyltransferase, DHHC domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR030290  Palmitoyltransferase ZDHHC13
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:1903830 magnesium ion transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015095 magnesium ion transmembrane transporter activity IEA
 molecular_functionGO:0016409 palmitoyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0019706 protein-cysteine S-palmitoyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: Not Specified

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001244 thin dermal layer "reduced thickness of the dermis" [J:65030]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: Not Specified

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flgft/Flgft
Genetic Background: Not Specified

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0002073 abnormal hair growth "absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mst1rtm1.1Sew/Mst1rtm1.1Sew
Genetic Background: involves: 129/Ola * CD-1 * NIH Black Swiss

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0004081 abnormal globus pallidus morphology "malformation of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zdhhc13skc4/Zdhhc13skc4
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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