ENSMUSG00000030738


Mus musculus

Features
Gene ID: ENSMUSG00000030738
  
Biological name :Eif3c
  
Synonyms : Eif3c / Eukaryotic translation initiation factor 3 subunit C / Q8R1B4
  
Possible biological names infered from orthology : B5ME19 / EIF3CL / eukaryotic translation initiation factor 3 subunit C like / Q99613
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126546455
Gene end: 126566411
  
Corresponding Affymetrix probe sets: 10567941 (MoGene1.0st)   1415858_at (Mouse Genome 430 2.0 Array)   1415859_at (Mouse Genome 430 2.0 Array)   1456083_x_at (Mouse Genome 430 2.0 Array)   1456374_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138023
Ensembl peptide - ENSMUSP00000146083
Ensembl peptide - ENSMUSP00000032992
NCBI entrez gene - 56347     See in Manteia.
MGI - MGI:1926966
RefSeq - NM_146200
RefSeq Peptide - NP_666312
swissprot - Q8R1B4
swissprot - A0A0U1RPR0
swissprot - M0QWV3
Ensembl - ENSMUSG00000030738
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif3cENSDARG00000016443Danio rerio
 B5ME19ENSG00000205609Homo sapiens
 EIF3CENSG00000184110Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR008905  Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR027516  Eukaryotic translation initiation factor 3 subunit C
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0045727 positive regulation of translation ISO
 biological_processGO:1902416 positive regulation of mRNA binding ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex IEA
 cellular_componentGO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031369 translation initiation factor binding IEA
 molecular_functionGO:0043022 ribosome binding ISO


Pathways (from Reactome)
Pathway description
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-ws/MitfMi-ws
Genetic Background: involves: C57BL/6

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Eif3cXs-J/Eif3c+
Genetic Background: B6C3Fe a/a-Eif3cXs-J/J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-ws/MitfMi-ws
Genetic Background: involves: C57BL/6

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Eif3cXs-J/Eif3c+
Genetic Background: B6C3Fe a/a-Eif3cXs-J/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MitfMi-ws/MitfMi-ws
Genetic Background: involves: C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0002177 abnormal outer ear morphology "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos2tm1Lau/Nos2tm1Lau,Tg(Thy1-APPSwDutIowa)BWevn/?
Genetic Background: involves: C57BL/6

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

Allelic Composition: Eif3cXs-J/Eif3c+
Genetic Background: B6C3Fe a/a-Eif3cXs-J/J

 MP:0002939 head spot "the appearance of a round area of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

 MP:0009049 abnormal hallux morphology "any structural anomaly of the first or primary digit of the foot" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif3cXs/Eif3c+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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