ENSMUSG00000030826


Mus musculus

Features
Gene ID: ENSMUSG00000030826
  
Biological name :Bcat2
  
Synonyms : Bcat2 / Branched-chain-amino-acid aminotransferase, mitochondrial / O35855
  
Possible biological names infered from orthology : branched chain amino acid transaminase 2 / O15382
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45570153
Gene end: 45589711
  
Corresponding Affymetrix probe sets: 10553015 (MoGene1.0st)   1425764_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147628
Ensembl peptide - ENSMUSP00000147303
Ensembl peptide - ENSMUSP00000148059
Ensembl peptide - ENSMUSP00000148152
Ensembl peptide - ENSMUSP00000033098
Ensembl peptide - ENSMUSP00000113045
NCBI entrez gene - 12036     See in Manteia.
MGI - MGI:1276534
RefSeq - XM_017321955
RefSeq - NM_001243052
RefSeq - NM_001243053
RefSeq - NM_009737
RefSeq - XM_017321953
RefSeq - XM_017321954
RefSeq Peptide - NP_001229981
RefSeq Peptide - NP_001229982
RefSeq Peptide - NP_033867
swissprot - O35855
swissprot - A0A1B0GX27
swissprot - A0A1B0GST1
swissprot - O88374
swissprot - Q3ULU3
swissprot - A0A1B0GQY4
Ensembl - ENSMUSG00000030826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcat2ENSDARG00000054849Danio rerio
 BCAT2ENSG00000105552Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcat1 / P24288 / Branched-chain-amino-acid aminotransferase, cytosolic / P54687* / branched chain amino acid transaminase 1*ENSMUSG0000003026855


Protein motifs (from Interpro)
Interpro ID Name
 IPR001544  Aminotransferase class IV
 IPR005786  Branched-chain amino acid aminotransferase II
 IPR018300  Aminotransferase, class IV, conserved site
 IPR033939  Branched-chain aminotransferase
 IPR036038  Aminotransferase-like, PLP-dependent enzymes


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006549 isoleucine metabolic process IMP
 biological_processGO:0006550 isoleucine catabolic process IMP
 biological_processGO:0006551 leucine metabolic process IMP
 biological_processGO:0006573 valine metabolic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0009081 branched-chain amino acid metabolic process IEA
 biological_processGO:0009082 branched-chain amino acid biosynthetic process IEA
 biological_processGO:0009083 branched-chain amino acid catabolic process IMP
 biological_processGO:0009098 leucine biosynthetic process IBA
 biological_processGO:0009099 valine biosynthetic process IBA
 biological_processGO:0010817 regulation of hormone levels IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004084 branched-chain-amino-acid transaminase activity IEA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0052654 L-leucine transaminase activity IEA
 molecular_functionGO:0052655 L-valine transaminase activity IEA
 molecular_functionGO:0052656 L-isoleucine transaminase activity IEA


Pathways (from Reactome)
Pathway description
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcat2mpc91H/Bcat2mpc91H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sgcatm2Kcam/Sgcatm2Kcam
Genetic Background: either: (129S6/SvEvTac-Sgcatm2Kcam) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0002893 ketoaciduria "excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0009351 thin hair shaft "the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011016 increased core body temperature "increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011468 abnormal urine amino acid level "any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group" [CHEBI:33709, MGI:csmith]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Bcat2tm1.2Clyn/Bcat2tm1.2Clyn
Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030826 Bcat2 / O35855 / Branched-chain-amino-acid aminotransferase, mitochondrial / O15382* / branched chain amino acid transaminase 2*  / complex






 

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