ENSMUSG00000030911


Mus musculus

Features
Gene ID: ENSMUSG00000030911
  
Biological name :Zp2
  
Synonyms : P20239 / zona pellucida glycoprotein 2 / Zp2
  
Possible biological names infered from orthology : Q05996
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F2
Gene start: 120126772
Gene end: 120145291
  
Corresponding Affymetrix probe sets: 10567526 (MoGene1.0st)   1449016_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033207
Ensembl peptide - ENSMUSP00000146926
Ensembl peptide - ENSMUSP00000147097
NCBI entrez gene - 22787     See in Manteia.
MGI - MGI:99214
RefSeq - XM_006507590
RefSeq - NM_011775
RefSeq - XM_006507589
RefSeq Peptide - NP_035905
swissprot - P20239
swissprot - Q3UX44
swissprot - A0A140LIR5
Ensembl - ENSMUSG00000030911
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-223m11.2ENSDARG00000017188Danio rerio
 si:dkey-19b23.11ENSDARG00000079034Danio rerio
 si:dkeyp-50f7.2ENSDARG00000069251Danio rerio
 ZP2ENSGALG00000002428Gallus gallus
 ZP2ENSG00000103310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zp1 / Q62005 / zona pellucida glycoprotein 1 / P60852*ENSMUSG0000002473419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001507  Zona pellucida domain
 IPR017977  Zona pellucida domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida IDA
 biological_processGO:0060468 prevention of polyspermy IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005771 multivesicular body IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032190 acrosin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0003406 failure of zygotic cell division "inability of a fertilized oocyte to initiate or complete early cell divisions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Blmtm1Ches/Blmtm4Ches,Tg(KLK3-cre)1Ches/0
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Tg(ZP2)2Dean/0,Tg(ZP3)7812Dean/?,Zp2tm1Dean/Zp2tm1Dean,Zp3tm1Dean/Zp3tm1Dean
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CF-1 * FVB/N

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0009372 abnormal cumulus oophorus "atypical formation of or inability to produce a mass of epithelial granulosa cells around the oocyte in the maturing Graafian follicle; the cumulus oophorus begins to expand dramatically when cumulus cells are induced to synthesize hyaluronic acid which aggregates in a viscous intercellular matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

 MP:0009375 thin zona pellucida "reduced thickness of the solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhbdf2cub/Rhbdf2cub,AregMcub/Areg+
Genetic Background: involves: C57BL/6J * STOCK a us/J * V/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr