ENSMUSG00000031015


Mus musculus

Features
Gene ID: ENSMUSG00000031015
  
Biological name :Swap70
  
Synonyms : Q6A028 / Swap70 / Switch-associated protein 70
  
Possible biological names infered from orthology : Q9UH65 / switching B cell complex subunit SWAP70
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 110221711
Gene end: 110283506
  
Corresponding Affymetrix probe sets: 10556280 (MoGene1.0st)   1423543_at (Mouse Genome 430 2.0 Array)   1434225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033325
NCBI entrez gene - 20947     See in Manteia.
MGI - MGI:1298390
RefSeq - NM_009302
RefSeq Peptide - NP_033328
swissprot - Q6A028
Ensembl - ENSMUSG00000031015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 swap70aENSDARG00000051819Danio rerio
 swap70bENSDARG00000057286Danio rerio
 SWAP70ENSGALG00000005750Gallus gallus
 Q9UH65ENSG00000133789Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Def6 / DEF6, guanine nucleotide exchange factor / Q9H4E7*ENSMUSG0000000225745


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0008064 regulation of actin polymerization or depolymerization IMP
 biological_processGO:0016444 somatic cell DNA recombination IDA
 biological_processGO:0030835 negative regulation of actin filament depolymerization IDA
 biological_processGO:0032233 positive regulation of actin filament bundle assembly IMP
 biological_processGO:0032880 regulation of protein localization IMP
 biological_processGO:0033633 negative regulation of cell-cell adhesion mediated by integrin IMP
 biological_processGO:0045190 isotype switching IDA
 biological_processGO:0051017 actin filament bundle assembly IDA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IMP
 biological_processGO:1902309 negative regulation of peptidyl-serine dephosphorylation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Dph1tm2Bhr/Dph1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dph1tm2Bhr/Dph1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Dph1tm2Bhr/Dph1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dph1tm2Bhr/Dph1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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