ENSMUSG00000031101


Mus musculus

Features
Gene ID: ENSMUSG00000031101
  
Biological name :Sash3
  
Synonyms : Q8K352 / SAM and SH3 domain-containing protein 3 / Sash3
  
Possible biological names infered from orthology : O75995 / SAM and SH3 domain containing 3
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A5
Gene start: 48146436
Gene end: 48161565
  
Corresponding Affymetrix probe sets: 10599487 (MoGene1.0st)   1427007_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033427
NCBI entrez gene - 74131     See in Manteia.
MGI - MGI:1921381
RefSeq - NM_028773
RefSeq - NM_001313749
RefSeq Peptide - NP_001300678
RefSeq Peptide - NP_083049
swissprot - Q8K352
Ensembl - ENSMUSG00000031101
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sash3ENSDARG00000016541Danio rerio
 SASH3ENSGALG00000032530Gallus gallus
 SASH3ENSG00000122122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sash1 / SAM and SH3 domain containing 1 / O94885*ENSMUSG0000001530541
P57725 / Samsn1 / SAM domain-containing protein SAMSN-1 / Q9NSI8* / SAM domain, SH3 domain and nuclear localization signals 1*ENSMUSG0000002287641


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR021090  SAM/SH3 domain-containing
 IPR035721  SAM and SH3 domain-containing protein 3, SH3 domain
 IPR035722  SAM and SH3 domain-containing protein 3
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002639 positive regulation of immunoglobulin production IMP
 biological_processGO:0002726 positive regulation of T cell cytokine production IMP
 biological_processGO:0002821 positive regulation of adaptive immune response IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032733 positive regulation of interleukin-10 production IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
 biological_processGO:0046622 positive regulation of organ growth IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0051251 positive regulation of lymphocyte activation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008193 abnormal marginal zone B cell physiology "abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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