ENSMUSG00000022876


Mus musculus

Features
Gene ID: ENSMUSG00000022876
  
Biological name :Samsn1
  
Synonyms : P57725 / SAM domain-containing protein SAMSN-1 / Samsn1
  
Possible biological names infered from orthology : Q9NSI8 / SAM domain, SH3 domain and nuclear localization signals 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.1
Gene start: 75858793
Gene end: 76022281
  
Corresponding Affymetrix probe sets: 10440393 (MoGene1.0st)   1421457_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109877
NCBI entrez gene - 67742     See in Manteia.
MGI - MGI:1914992
RefSeq - NM_023380
RefSeq Peptide - NP_075869
swissprot - P57725
Ensembl - ENSMUSG00000022876
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 samsn1aENSDARG00000054543Danio rerio
 samsn1bENSDARG00000078647Danio rerio
 SAMSN1ENSGALG00000040926Gallus gallus
 Q9NSI8ENSG00000155307Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sash1 / SAM and SH3 domain containing 1 / O94885*ENSMUSG0000001530542
Sash3 / Q8K352 / SAM and SH3 domain-containing protein 3 / O75995* / SAM and SH3 domain containing 3*ENSMUSG0000003110142


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR021090  SAM/SH3 domain-containing
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002820 negative regulation of adaptive immune response IMP
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050869 negative regulation of B cell activation IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Tnfsf4tm1Shr/Tnfsf4tm1Shr
Genetic Background: C.129S4-Tnfsf4tm1Shr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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