Manteia - Molecule gene

ENSMUSG00000031173

Mus musculus

Features

Gene ID:	ENSMUSG00000031173

Biological name :	Otc

Synonyms :	Ornithine carbamoyltransferase, mitochondrial / Otc / P11725

Possible biological names infered from orthology :	ornithine carbamoyltransferase / P00480

Species:	Mus musculus

Chr. number:	X
Strand:	1
Band:	A1.1
Gene start:	10252305
Gene end:	10321024

Corresponding Affymetrix probe sets:	10598612 (MoGene1.0st) 1420525_a_at (Mouse Genome 430 2.0 Array) 1425540_at (Mouse Genome 430 2.0 Array) 1436615_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000056152 Ensembl peptide - ENSMUSP00000111190 NCBI entrez gene - 18416 See in Manteia. MGI - MGI:97448 RefSeq - XM_011247449 RefSeq - NM_008769 RefSeq Peptide - NP_032795 swissprot - P11725 swissprot - Q543H3 swissprot - Q8R1A8 Ensembl - ENSMUSG00000031173

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
otc	ENSDARG00000062147	Danio rerio
OTC	ENSGALG00000016254	Gallus gallus
OTC	ENSG00000036473	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR002292	Ornithine/putrescine carbamoyltransferase
IPR006130	Aspartate/ornithine carbamoyltransferase
IPR006131	Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain
IPR006132	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding
IPR036901	Aspartate/ornithine carbamoyltransferase superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000050	urea cycle	ISO
biological_process	GO:0001889	liver development	IEA
biological_process	GO:0006520	cellular amino acid metabolic process	IEA
biological_process	GO:0006526	arginine biosynthetic process	IEA
biological_process	GO:0006591	ornithine metabolic process	IEA
biological_process	GO:0006593	ornithine catabolic process	IEA
biological_process	GO:0007494	midgut development	IEA
biological_process	GO:0008652	cellular amino acid biosynthetic process	IEA
biological_process	GO:0010043	response to zinc ion	IEA
biological_process	GO:0019240	citrulline biosynthetic process	IEA
biological_process	GO:0031667	response to nutrient levels	IEA
biological_process	GO:0032868	response to insulin	IEA
biological_process	GO:0042450	arginine biosynthetic process via ornithine	IBA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0055081	anion homeostasis	IEA
biological_process	GO:0070207	protein homotrimerization	IEA
biological_process	GO:0070781	response to biotin	IEA
biological_process	GO:0097272	ammonia homeostasis	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	ISO
cellular_component	GO:0005743	mitochondrial inner membrane	IEA
cellular_component	GO:0005759	mitochondrial matrix	IEA
molecular_function	GO:0004585	ornithine carbamoyltransferase activity	ISO
molecular_function	GO:0005543	phospholipid binding	IEA
molecular_function	GO:0016597	amino acid binding	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0016743	carboxyl- or carbamoyltransferase activity	IEA
molecular_function	GO:0042301	phosphate ion binding	IEA

Pathways (from Reactome)

Pathway description

Mitochondrial protein import

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Otc^spf-ash/Otc⁺ Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J Allelic Composition: Acads^del-J/Acads^del-J,Otc^spf/Y Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J Allelic Composition: Otc^spf/Otc^spf Genetic Background: Not Specified Allelic Composition: Otc^spf-J/Y Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0000418	patchy hair	"uneven spots of hair growth on the body" [J:26975]	Show Allelic Composition: Otc^spf/Otc^spf Genetic Background: involves: CD-1 Allelic Composition: Otc^spf-J/Otc⁺ Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0000422	delayed hair appearance	"late onset of the first appearance of the fur" [J:17792]	Show Allelic Composition: Otc^spf/Otc^spf Genetic Background: involves: CD-1
MP:0000436	abnormal head movements	"anomalous motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Myf5^tm2Tajb/Myf5⁺,Tbx1^tm1Pa/Tbx1^tm1Pa Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Sun1^tm1Mhan/Sun1⁺,Sun2^tm1Mhan/Sun2^tm1Mhan Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0000774	reduced brain size	"smaller appearance of the brain" [J:35802]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0001038	abnormal cholinergic neuron morphology	"malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0001211	wrinkled skin	"irregular folds and/or indentations on the skin" [J:19212]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J Allelic Composition: Otc^spf/Otc^spf Genetic Background: Not Specified
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J Allelic Composition: Otc^spf/Otc^spf Genetic Background: Not Specified Allelic Composition: Otc^spf-ash/Y Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J Allelic Composition: Otc^spf-J/Y Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Trim63^tm2.1Vlcg/Trim63^tm2.1Vlcg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001442	decreased grooming behavior	"reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Otc^spf-ash/Y Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J
MP:0001510	abnormal coat appearance	"coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otc^spf/Otc^spf Genetic Background: Not Specified
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Tdgf1^tm1Eda/Tdgf1^tm1Eda Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001777	abnormal body temperature regulation	"anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Myf5^tm2Tajb/Myf5⁺,Tbx1^tm1Pa/Tbx1^tm1Pa Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0002073	abnormal hair growth	"absence or reduced amount of hair or abnormal onset of hair growth cycle or development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd3e^tm1Cpt/Cd3e^tm1Cpt,Tg(CD3E)26Cpt/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fzr1^Gt(3003)Tgen/Fzr1^Gt(3003)Tgen Genetic Background: involves: C57BL/6 * CBA
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Acads^del-J/Acads^del-J,Otc^spf/Y Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Acads^del-J/Acads^del-J,Otc^spf/Otc^spf Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: C57BL/6 Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0003415	priapism	"prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0003806	abnormal nucleotide metabolism	"impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0003997	tonic-clonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0004000	impaired passive avoidance behavior	"decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0005010	abnormal CD8+ T cell morphology/development	"anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0005027	increased susceptibility to parasitic infection	"greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Tdgf1^tm1Eda/Tdgf1^tm1Eda Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005266	abnormal metabolism	"anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Otc^spf-ash/Otc⁺ Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0005309	increased circulating ammonia level	"significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Otc^spf/Otc^spf Genetic Background: involves: CD-1 Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1 Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J Allelic Composition: Otc^spf-ash/Y Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J
MP:0005311	abnormal circulating amino acid level	"aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]	Show Allelic Composition: Otc^spf/Otc^spf Genetic Background: involves: CD-1 Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J Allelic Composition: Otc^spf-J/Y Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0005332	abnormal amino acid level	"aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Otc^spf/Otc^spf Genetic Background: involves: CD-1 Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1 Allelic Composition: Otc^spf-J/Y Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Otc^spf/Otc⁺ Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0006036	abnormal mitochondrial physiology		Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008097	increased plasma cell number	"greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008143	abnormal dendrite morphology	"any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0008414	abnormal spatial reference memory	"anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf-ash/Y Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J
MP:0008428	abnormal spatial working memory	"anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf-ash/Y Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J
MP:0008469	abnormal protein level	"anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008699	increased interleukin-4 secretion	"increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008705	increased interleukin-6 secretion	"increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Cd4^tm1Litt/Cd4^tm1Litt,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008735	increased susceptibility to endotoxin shock	"more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf-ash/Y Genetic Background: B6EiC3Sn a/A-Otc^spf-ash/J
MP:0008751	abnormal interleukin level	"deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl * 129S2/SvPas
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf-J/Y Genetic Background: C57BL/6J-Otc^spf-J/J
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Otc^spf/Y Genetic Background: involves: C3H/HeJ * C57BL/6J
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cer1^tm1Belo/Cer1^tm1Belo,Tdgf1^tm1Eda/Tdgf1^tm1Eda Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009969	abnormal cerebral cortex pyramidal cell morphology	"any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0010028	aciduria	"excretion of an acid urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Acads^del-J/Acads^del-J,Otc^spf/Y Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Acads^del-J/Acads^del-J,Otc^spf/Otc⁺ Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Acads^del-J/Acads⁺,Otc^spf/Y Genetic Background: involves: BALB/cByJ * CD-1
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Foxp3^sf Otc^spf/Y Genetic Background: involves: 129/Rl
MP:0011380	enlarged brain ventricle	"increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified
MP:0011588	decreased ornithine carbamoyltransferase activity	"reduced ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline" [GO:0004585]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Otc^spf/Otc⁺ Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1
MP:0011626	orotic acid urinary bladder stones	"presence of caliculi, or a solid concretion or crystal aggregation formed from orotic acid, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith]	Show Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: 22A/R * C57BL/6J
MP:0011765	oroticaciduria	"increased level of orotic acid, an intermediate of pyrimidine synthesis, in the urine" [MGI:anna]	Show Allelic Composition: Irs4^tm1Lhd/Y Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Otc^spf/Otc⁺ Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: Not Specified Allelic Composition: Otc^spf/Y Genetic Background: involves: CD-1 Allelic Composition: Acads^del-J/Acads⁺,Otc^spf/Y Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Acads^del-J/Acads^del-J,Otc^spf/Otc^spf Genetic Background: involves: BALB/cByJ * CD-1 Allelic Composition: Otc^spf-ash/Y Genetic Background: involves: C57BL/6 Allelic Composition: Otc^spf-ash/Otc⁺ Genetic Background: involves: C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031173	Otc / P11725 / Ornithine carbamoyltransferase, mitochondrial / P00480* / ornithine carbamoyltransferase*	/ complex

1 s.

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