ENSMUSG00000031342


Mus musculus

Features
Gene ID: ENSMUSG00000031342
  
Biological name :Gpm6b
  
Synonyms : glycoprotein m6b / Gpm6b / P35803
  
Possible biological names infered from orthology : Q13491
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 166238911
Gene end: 166388988
  
Corresponding Affymetrix probe sets: 10603151 (MoGene1.0st)   1423091_a_at (Mouse Genome 430 2.0 Array)   1425942_a_at (Mouse Genome 430 2.0 Array)   1453514_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134741
Ensembl peptide - ENSMUSP00000107854
Ensembl peptide - ENSMUSP00000135378
Ensembl peptide - ENSMUSP00000060442
Ensembl peptide - ENSMUSP00000107842
Ensembl peptide - ENSMUSP00000107843
Ensembl peptide - ENSMUSP00000107845
Ensembl peptide - ENSMUSP00000107846
Ensembl peptide - ENSMUSP00000107847
Ensembl peptide - ENSMUSP00000107848
Ensembl peptide - ENSMUSP00000107852
NCBI entrez gene - 14758     See in Manteia.
MGI - MGI:107672
RefSeq - XM_017318385
RefSeq - NM_001177955
RefSeq - NM_001177956
RefSeq - NM_001177957
RefSeq - NM_001177958
RefSeq - NM_001177959
RefSeq - NM_001177960
RefSeq - NM_001177961
RefSeq - NM_001177962
RefSeq - NM_023122
RefSeq - XM_011247784
RefSeq Peptide - NP_001171432
RefSeq Peptide - NP_001171433
RefSeq Peptide - NP_075611
RefSeq Peptide - NP_001171428
RefSeq Peptide - NP_001171429
RefSeq Peptide - NP_001171426
RefSeq Peptide - NP_001171427
RefSeq Peptide - NP_001171430
RefSeq Peptide - NP_001171431
swissprot - Q3V0Z9
swissprot - H3BIV8
swissprot - A2AEG6
swissprot - P35803
swissprot - Q3US81
swissprot - A2AEG3
Ensembl - ENSMUSG00000031342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpm6baENSDARG00000005739Danio rerio
 gpm6bbENSDARG00000001676Danio rerio
 GPM6BENSGALG00000016575Gallus gallus
 GPM6BENSG00000046653Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpm6a / P35802 / glycoprotein m6a / P51674*ENSMUSG0000003151745
Plp1 / P60202 / proteolipid protein (myelin) 1 / P60201* / proteolipid protein 1*ENSMUSG0000003142540


Protein motifs (from Interpro)
Interpro ID Name
 IPR001614  Myelin proteolipid protein PLP
 IPR018237  Myelin proteolipid protein PLP, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030501 positive regulation of bone mineralization ISS
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISS
 biological_processGO:0051612 negative regulation of serotonin uptake IDA
 biological_processGO:0051893 regulation of focal adhesion assembly ISO
 biological_processGO:0085029 extracellular matrix assembly ISO
 biological_processGO:2000009 negative regulation of protein localization to cell surface IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpm6btm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpm6btm1Kan/Gpm6btm1Kan,Plp1tm1Kan/Plp1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Gpm6btm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dpp4tm1Lex/Dpp4tm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Gpm6btm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010749 absent visual evoked potential "absence of a characteristic electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; absence may indicate blindness" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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