| MP:0000136 | abnormal microglial cell morphology | "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688] |
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1jp-rsh/Plp1+
Genetic Background: either: STOCK Rb(1.3)1Bnr or (involves: BALB/c * DBA/2 * STOCK Rb(1.3)1Bnr)
|
| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
|
| MP:0000743 | muscle spasms | "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Mbpshi/Mbpshi,Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV
Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: C57BL/10Sn * BALB/cJ
Allelic Composition: Plp1jp-msd/Y
Genetic Background: B6C3-EdaTa Plp1jp-msd
Allelic Composition: Plp1jp/Y
Genetic Background: B6C3-EdaTa Plp1jp
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Plp1jp-6J/Y
Genetic Background: BALB/cJ-Plp1jp-6J/GrsrJ
|
| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
|
| MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000849 | abnormal cerebellum morphology | "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
|
| MP:0000886 | abnormal cerebellar granule layer | "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
|
| MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
|
| MP:0000920 | abnormal myelination | "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm2Wst/Plp1tm2Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm3Wst/Plp1tm3Wst
Genetic Background: B6.129S1-Plp1tm3Wst
Allelic Composition: Mbpshi/Mbpshi,Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV
Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: BALB/c * C57BL/6J * C57BL/10
Allelic Composition: Plp1jp-msd/Plp1jp-msd
Genetic Background: involves: BALB/c * C57BL/6J * C57BL/10
Allelic Composition: Plp1jp-rsh/Plp1+
Genetic Background: either: STOCK Rb(1.3)1Bnr or (involves: BALB/c * DBA/2 * STOCK Rb(1.3)1Bnr)
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: C57BL/10Sn * BALB/cJ
Allelic Composition: Plp1jp/Y
Genetic Background: B6C3-EdaTa Plp1jp
Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Mbpshi/Mbpshi,Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SWV
Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca
Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Plp1jp-rsh/Plp1+
Genetic Background: either: STOCK Rb(1.3)1Bnr or (involves: BALB/c * DBA/2 * STOCK Rb(1.3)1Bnr)
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: C57BL/10Sn * BALB/cJ
Allelic Composition: Plp1jp-msd/Y
Genetic Background: B6C3-EdaTa Plp1jp-msd
Allelic Composition: Plp1jp/Y
Genetic Background: B6C3-EdaTa Plp1jp
Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
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| MP:0000952 | abnormal CNS glia | "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0000953 | abnormal oligodendrocyte morphology | "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm1Wst/Plp1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm2Wst/Plp1tm2Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm2Wst/Plp1+
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1jp-rsh/Plp1+
Genetic Background: either: STOCK Rb(1.3)1Bnr or (involves: BALB/c * DBA/2 * STOCK Rb(1.3)1Bnr)
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Plp1jp-msd/Y
Genetic Background: B6C3-EdaTa Plp1jp-msd
Allelic Composition: Plp1jp/Y
Genetic Background: B6C3-EdaTa Plp1jp
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
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| MP:0001290 | delayed eyelid opening | "late average time for the first postnatal eye opening" [J:17792] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
|
| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001330 | abnormal optic nerve morphology | "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1tm2Wst/Plp1+
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001388 | abnormal stationary movement | "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Mbpshi/Mbpshi,Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV
Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm2Wst/Plp1tm2Wst
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm2Wst/Plp1tm2Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca
Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
|
| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0001486 | abnormal startle reflex | "abberant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
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| MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0001847 | brain inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
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| MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: C57BL/10Sn * BALB/cJ
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| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: BALB/c * C3H * C57BL/6 * C57BL/10
Allelic Composition: Casp12tm1Yuan/Casp12tm1Yuan,Plp1jp-msd/Y
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 * BALB/c
Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: BALB/c * C57BL/6J * C57BL/10
Allelic Composition: Plp1jp-msd/Plp1jp-msd
Genetic Background: involves: BALB/c * C57BL/6J * C57BL/10
Allelic Composition: Plp1jp/Y
Genetic Background: B6C3-EdaTa Plp1jp
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gpm6btm1Kan/Gpm6btm1Kan,Plp1tm1Kan/Plp1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Gpm6btm1Kan/Gpm6b+,Plp1tm1Kan/Plp1tm1Kan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Plp1jp-6J/Y
Genetic Background: BALB/cJ-Plp1jp-6J/GrsrJ
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
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| MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
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| MP:0002183 | gliosis | "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
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| MP:0002410 | decreased susceptibility to viral infection | "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mbpshi/Mbpshi
Genetic Background: involves: SWV
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| MP:0002675 | asthenozoospermia | "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1jp-6J/Y
Genetic Background: BALB/cJ-Plp1jp-6J/GrsrJ
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| MP:0002687 | oligozoospermia | "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
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Allelic Composition: Plp1jp-6J/Y
Genetic Background: BALB/cJ-Plp1jp-6J/GrsrJ
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| MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0003312 | abnormal locomotor coordination | "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
Allelic Composition: Casp12tm1Yuan/Casp12tm1Yuan,Plp1jp-rsh/Y
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Twist1Pas/Twist1Pas
Genetic Background: involves: C57BL/6 * PDT/Pas
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
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| MP:0003634 | abnormal glia | "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C57BL/6NCrl
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0003871 | abnormal myelin sheath morphology | "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm3Wst/Plp1tm3Wst
Genetic Background: B6.129S1-Plp1tm3Wst
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Mbpshi/Mbpshi,Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV
Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca
Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
Allelic Composition: Plp1jp-rsh/Plp1jp-rsh
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0003983 | decreased cholesterol level | "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0003997 | tonic-clonic seizures | "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
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| MP:0004143 | hypertonia | "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0004768 | abnormal axonal transport | "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
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| MP:0004777 | abnormal phospholipid level | "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plp1jp-rsh/Plp1jp-rsh
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
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| MP:0005403 | abnormal nerve conduction | "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm2Wst/Plp1tm2Wst
Genetic Background: involves: 129P2/OlaHsd
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1tm1Kan/Plp1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005405 | axon degeneration | "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca
Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs
Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: BALB/c * C3H * C57BL/6 * C57BL/10
Allelic Composition: Casp12tm1Yuan/Casp12tm1Yuan,Plp1jp-rsh/Y
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * STOCK Rb(1.3)1Bnr
Allelic Composition: Casp12tm1Yuan/Casp12tm1Yuan,Plp1jp-msd/Y
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10 * BALB/c
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0006325 | impaired hearing | "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0008026 | abnormal brain white matter morphology | "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0008226 | decreased anterior commissure size | "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0008916 | abnormal astrocyte physiology | "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
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| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
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| MP:0009358 | environmentally induced seizures | "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
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| MP:0009434 | paraparesis | "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Plp1jp/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1Kan/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0009808 | reduced oligodendrocyte number | "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0009978 | abnormal cerebellum white matter morphology | |
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Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
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| MP:0010047 | axonal spheroids | "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421] |
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Allelic Composition: Plp1tm1Wst/Plp1tm1Wst
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Mbpshi/Mbpshi,Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * SWV
Allelic Composition: Plp1tm1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified
Allelic Composition: Plp1tm1Kan/Y,Tspan2tm1Hbw/Tspan2tm1Hbw
Genetic Background: B6.Cg-Tspan2tm1Hbw Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6.129-Plp1tm1Kan
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6N.129-Plp1tm1Kan
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| MP:0010160 | increased oligodendrocyte number | "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1jp-rsh/Plp1+
Genetic Background: either: STOCK Rb(1.3)1Bnr or (involves: BALB/c * DBA/2 * STOCK Rb(1.3)1Bnr)
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| MP:0010205 | abnormal oligodendrocyte apoptosis | "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0010749 | absent visual evoked potential | "absence of a characteristic electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; absence may indicate blindness" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0011083 | complete lethality at weaning | "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith] |
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Allelic Composition: Plp1jp-4J/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Plp1jp-msd/Y
Genetic Background: involves: C57BL/10Sn * BALB/cJ
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| MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0011966 | abnormal auditory brainstem response waveform shape | "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith] |
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Allelic Composition: Gpm6btm1Kan Plp1tm1Kan/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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| MP:0012674 | tomacula | "focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded" [MGI:smb] |
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Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6N.129-Plp1tm1Kan
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| MP:0013438 | dysmyelination | "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith] |
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Allelic Composition: Plp1jp-rsh/Y
Genetic Background: involves: 101 * C3H
Allelic Composition: Plp1tm1Kan/Y
Genetic Background: B6N.129-Plp1tm1Kan
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| MP:0020351 | decreased vocalization | "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702] |
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Allelic Composition: Grhl3ct/Grhl3tm1Jane
Genetic Background: involves: 129S1/Sv * C57BL/6 * STOCK ct/J
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