ENSMUSG00000031447


Mus musculus

Features
Gene ID: ENSMUSG00000031447
  
Biological name :Lamp1
  
Synonyms : Lamp1 / Lysosome-associated membrane glycoprotein 1 / P11438
  
Possible biological names infered from orthology : lysosomal associated membrane protein 1 / P11279
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 13159161
Gene end: 13175338
  
Corresponding Affymetrix probe sets: 10570344 (MoGene1.0st)   1415880_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033824
NCBI entrez gene - 16783     See in Manteia.
MGI - MGI:96745
RefSeq - NM_010684
RefSeq - NM_001317353
RefSeq Peptide - NP_001304282
RefSeq Peptide - NP_034814
swissprot - P11438
swissprot - Q3TA96
Ensembl - ENSMUSG00000031447
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamp1ENSDARG00000092610Danio rerio
 LAMP1ENSDARG00000100181Danio rerio
 LAMP1ENSGALG00000037697Gallus gallus
 LAMP1ENSG00000185896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamp2 / P17047 / Lysosome-associated membrane glycoprotein 2 / P13473* / lysosomal associated membrane protein 2*ENSMUSG0000001653435
Cd68 / P31996 / Macrosialin / P34810* / CD68 molecule*ENSMUSG0000001877420
Lamp3 / Q7TST5 / Lysosome-associated membrane glycoprotein 3 / Q9UQV4* / lysosomal associated membrane protein 3*ENSMUSG0000004124716


Protein motifs (from Interpro)
Interpro ID Name
 IPR002000  Lysosome-associated membrane glycoprotein
 IPR018134  Lysosome-associated membrane glycoprotein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IEA
 biological_processGO:0043323 positive regulation of natural killer cell degranulation IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0048102 autophagic cell death IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0072594 establishment of protein localization to organelle IEA
 biological_processGO:0090160 Golgi to lysosome transport IEA
 biological_processGO:1902513 regulation of organelle transport along microtubule IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0010008 endosome membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042470 melanosome IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044194 cytolytic granule IDA
 cellular_componentGO:0044754 autolysosome IDA
 cellular_componentGO:0045335 phagocytic vesicle IMP
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0061474 phagolysosome membrane IDA
 cellular_componentGO:0097208 alveolar lamellar body IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000454 abnormal jaw morphology "malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Kcnma1tm1Rwa/Kcnma1tm1Rwa
Genetic Background: FVB.129-Kcnma1tm1Rwa

Allelic Composition: Lamp1tm1Psa/Lamp1tm1Psa,Lamp2tm1Psa/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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