ENSMUSG00000031523


Mus musculus

Features
Gene ID: ENSMUSG00000031523
  
Biological name :Dlc1
  
Synonyms : Dlc1 / DLC1 Rho GTPase activating protein
  
Possible biological names infered from orthology : Q96QB1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 36567751
Gene end: 36953143
  
Corresponding Affymetrix probe sets: 10578222 (MoGene1.0st)   10578241 (MoGene1.0st)   1436173_at (Mouse Genome 430 2.0 Array)   1450206_at (Mouse Genome 430 2.0 Array)   1458220_at (Mouse Genome 430 2.0 Array)   1460602_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096425
Ensembl peptide - ENSMUSP00000137498
Ensembl peptide - ENSMUSP00000132812
Ensembl peptide - ENSMUSP00000033923
NCBI entrez gene - 50768     See in Manteia.
MGI - MGI:1354949
RefSeq - XM_017312892
RefSeq - NM_001194940
RefSeq - NM_001194941
RefSeq - NM_015802
RefSeq - XM_006509166
RefSeq Peptide - NP_001181869
RefSeq Peptide - NP_056617
RefSeq Peptide - NP_001181870
swissprot - A0A0R4J171
swissprot - E9PXD2
swissprot - E9QKB1
swissprot - J3QPV2
Ensembl - ENSMUSG00000031523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlc1ENSDARG00000079317Danio rerio
 DLC1ENSGALG00000013715Gallus gallus
 DLC1ENSG00000164741Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q923Q2 / Stard13 / StAR-related lipid transfer protein 13 / Q9Y3M8* / StAR related lipid transfer domain containing 13*ENSMUSG0000001612839
Q8K031 / Stard8 / StAR-related lipid transfer protein 8 / Q92502* / StAR related lipid transfer domain containing 8*ENSMUSG0000003121628
Q8K0Q5 / Arhgap18 / Rho GTPase-activating protein 18 / Q8N392*ENSMUSG000000390319
Q8BN58 / Arhgap28 / Mus musculus Rho GTPase activating protein 28 (Arhgap28), transcript variant 2, mRNA. / Q9P2N2* / Rho GTPase activating protein 28*ENSMUSG000000240438
E9Q6X9 / Arhgap40 / Rho GTPase-activating protein 40 / Q5TG30*ENSMUSG000000746258
O54834 / Arhgap6 / Rho GTPase activating protein 6 / O43182*ENSMUSG000000313558
Q80Y19 / Arhgap11a / Rho GTPase-activating protein 11A / Q6P4F7*ENSMUSG000000412196
B1AUC7 / Arhgap36 / Mus musculus Rho GTPase activating protein 36 (Arhgap36), transcript variant 2, mRNA. / Q6ZRI8* / Rho GTPase activating protein 36*ENSMUSG000000361986
Gm42906ENSMUSG000001070111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001660  Sterile alpha motif domain
 IPR002913  START domain
 IPR008936  Rho GTPase activation protein
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR023393  START-like domain superfamily
 IPR028854  Rho GTPase-activating protein 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly IEA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001889 delayed brain development "the delay or slower progress of the growth and differentiation of the brain" [J:81818, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dlc1tm1.1Lowy/Dlc1tm1.1Lowy
Genetic Background: involves: 129 * C57BL/6

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Mmcm/Braf+,Ptentm1Mro/Ptentm1Mro,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: B6.Cg-Braftm1Mmcm Ptentm1Mro Tg(Tyr-cre/ERT2)1Lru

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002884 abnormal branchial arches "malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlc1tm1.1Lowy/Dlc1tm1.1Lowy
Genetic Background: involves: 129 * C57BL/6

 MP:0006108 abnormal hindbrain development "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011709 increased fibroblast cell migration "greater frequency of or more rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Dlc1Gt(XE082)Byg/Dlc1Gt(XE082)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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