ENSMUSG00000031633


Mus musculus

Features
Gene ID: ENSMUSG00000031633
  
Biological name :Slc25a4
  
Synonyms : P48962 / Slc25a4 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
  
Possible biological names infered from orthology : P12235 / solute carrier family 25 member 4
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B1.1
Gene start: 46206797
Gene end: 46211284
  
Corresponding Affymetrix probe sets: 10578539 (MoGene1.0st)   1424562_a_at (Mouse Genome 430 2.0 Array)   1424563_at (Mouse Genome 430 2.0 Array)   1434897_a_at (Mouse Genome 430 2.0 Array)   1455069_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034049
NCBI entrez gene - 11739     See in Manteia.
MGI - MGI:1353495
RefSeq - NM_007450
RefSeq Peptide - NP_031476
swissprot - P48962
Ensembl - ENSMUSG00000031633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc25a4ENSDARG00000027355Danio rerio
 SLC25A4ENSGALG00000010614Gallus gallus
 P12235ENSG00000151729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51881 / Slc25a5 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 / P05141* / solute carrier family 25 member 5*ENSMUSG0000001631990
Q3V132 / Slc25a31 / solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 / Q9H0C2* / solute carrier family 25 member 31*ENSMUSG0000006904171


Protein motifs (from Interpro)
Interpro ID Name
 IPR002067  Mitochondrial carrier protein
 IPR002113  Adenine nucleotide translocator 1
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008637 apoptotic mitochondrial changes IGI
 biological_processGO:0015866 ADP transport IEA
 biological_processGO:0015867 ATP transport IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0032592 integral component of mitochondrial membrane ISS
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005471 ATP:ADP antiporter activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002332 abnormal exercise endurance "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Slc25a4tm2Dwa/Slc25a4tm2Dwa
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
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Allelic Composition: Slc25a4tm2Dwa/Slc25a4tm2Dwa
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024944 Arl2 / Q9D0J4 / ADP-ribosylation factor-like protein 2 / P36404* / ARL2-SNX15* / ADP ribosylation factor like GTPase 2* / ARL2-SNX15 readthrough (NMD candidate)*  / reaction / complex
 ENSMUSG00000031776 Arl2bp / Q9D385 / ADP-ribosylation factor-like protein 2-binding protein / Q9Y2Y0* / ADP ribosylation factor like GTPase 2 binding protein*  / complex / reaction






 

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