ENSMUSG00000031633


Mus musculus

Features
Gene ID: ENSMUSG00000031633
  
Biological name :Slc25a4
  
Synonyms : P48962 / Slc25a4 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
  
Possible biological names infered from orthology : P12235 / solute carrier family 25 member 4
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B1.1
Gene start: 46206797
Gene end: 46211284
  
Corresponding Affymetrix probe sets: 10578539 (MoGene1.0st)   1424562_a_at (Mouse Genome 430 2.0 Array)   1424563_at (Mouse Genome 430 2.0 Array)   1434897_a_at (Mouse Genome 430 2.0 Array)   1455069_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034049
NCBI entrez gene - 11739     See in Manteia.
MGI - MGI:1353495
RefSeq - NM_007450
RefSeq Peptide - NP_031476
swissprot - P48962
Ensembl - ENSMUSG00000031633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc25a4ENSDARG00000027355Danio rerio
 SLC25A4ENSGALG00000010614Gallus gallus
 P12235ENSG00000151729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P51881 / Slc25a5 / solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 / P05141* / solute carrier family 25 member 5*ENSMUSG0000001631990
Q3V132 / Slc25a31 / solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 / Q9H0C2* / solute carrier family 25 member 31*ENSMUSG0000006904171


Protein motifs (from Interpro)
Interpro ID Name
 IPR002067  Mitochondrial carrier protein
 IPR002113  Adenine nucleotide translocator 1
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008637 apoptotic mitochondrial changes IGI
 biological_processGO:0015866 ADP transport IEA
 biological_processGO:0015867 ATP transport IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0032592 integral component of mitochondrial membrane ISS
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0005471 ATP:ADP antiporter activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022857 transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
Regulation of insulin secretion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002332 abnormal exercise endurance "improved or impaired performance during controlled physical activity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0004151 hypoferremia "less than the normal concentration of this metallic element in the blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
Show

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Slc25a4tm2Dwa/Slc25a4tm2Dwa
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Slc25a4tm2Dwa/Slc25a4tm2Dwa
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024944 Arl2 / Q9D0J4 / ADP-ribosylation factor-like protein 2 / P36404* / ARL2-SNX15* / ADP ribosylation factor like GTPase 2* / ARL2-SNX15 readthrough (NMD candidate)*  / reaction / complex
 ENSMUSG00000031776 Arl2bp / Q9D385 / ADP-ribosylation factor-like protein 2-binding protein / Q9Y2Y0* / ADP ribosylation factor like GTPase 2 binding protein*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr