ENSMUSG00000031770


Mus musculus

Features
Gene ID: ENSMUSG00000031770
  
Biological name :Herpud1
  
Synonyms : Herpud1 / Mus musculus homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (Herpud1), transcript variant 2, mRNA. / Q9JJK5
  
Possible biological names infered from orthology : homocysteine inducible ER protein with ubiquitin like domain 1 / Q15011
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 94386438
Gene end: 94395377
  
Corresponding Affymetrix probe sets: 10574087 (MoGene1.0st)   1435626_a_at (Mouse Genome 430 2.0 Array)   1448185_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148426
Ensembl peptide - ENSMUSP00000148775
Ensembl peptide - ENSMUSP00000148581
Ensembl peptide - ENSMUSP00000034220
Ensembl peptide - ENSMUSP00000124201
NCBI entrez gene - 64209     See in Manteia.
MGI - MGI:1927406
RefSeq - NM_001357205
RefSeq - XM_006531260
RefSeq - NM_022331
RefSeq Peptide - NP_001344134
RefSeq Peptide - NP_071726
swissprot - A0A1D5RMG9
swissprot - A0A1D5RM09
swissprot - Q3TMN9
swissprot - Q8C4N0
swissprot - Q9JJK5
swissprot - A0A1D5RLM1
Ensembl - ENSMUSG00000031770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herpud1ENSDARG00000024314Danio rerio
 HERPUD1ENSGALG00000001220Gallus gallus
 Q15011ENSG00000051108Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JJC9 / Herpud2 / Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein / Q9BSE4* / HERPUD family member 2*ENSMUSG0000000842941


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IEA
 biological_processGO:0031396 regulation of protein ubiquitination IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:1990037 Lewy body core IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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