ENSMUSG00000032327


Mus musculus

Features
Gene ID: ENSMUSG00000032327
  
Biological name :Stra6
  
Synonyms : stimulated by retinoic acid gene 6 / Stra6
  
Possible biological names infered from orthology : Q9BX79 / stimulated by retinoic acid 6
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 58063788
Gene end: 58153996
  
Corresponding Affymetrix probe sets: 10585803 (MoGene1.0st)   1422723_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114346
Ensembl peptide - ENSMUSP00000130232
Ensembl peptide - ENSMUSP00000128417
Ensembl peptide - ENSMUSP00000122373
Ensembl peptide - ENSMUSP00000119062
Ensembl peptide - ENSMUSP00000118242
Ensembl peptide - ENSMUSP00000117832
Ensembl peptide - ENSMUSP00000117280
Ensembl peptide - ENSMUSP00000115511
Ensembl peptide - ENSMUSP00000115315
Ensembl peptide - ENSMUSP00000115314
Ensembl peptide - ENSMUSP00000034880
Ensembl peptide - ENSMUSP00000082820
NCBI entrez gene - 20897     See in Manteia.
MGI - MGI:107742
RefSeq - XM_017313262
RefSeq - NM_001162475
RefSeq - NM_001162476
RefSeq - NM_001162479
RefSeq - NM_009291
RefSeq - XM_006510941
RefSeq - XM_006510943
RefSeq - XM_006510944
RefSeq - XM_006510945
RefSeq - XM_006510946
RefSeq Peptide - NP_001155947
RefSeq Peptide - NP_033317
RefSeq Peptide - NP_001155951
RefSeq Peptide - NP_001155948
swissprot - E9PZT7
swissprot - E9PZN4
swissprot - D3YXW9
swissprot - D3YVZ1
swissprot - D3YUA2
swissprot - A0A0R4J115
swissprot - E9Q9S7
swissprot - E9QAQ2
swissprot - E9Q3G2
swissprot - E9Q283
Ensembl - ENSMUSG00000032327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stra6ENSDARG00000051874Danio rerio
 STRA6ENSGALG00000001449Gallus gallus
 STRA6ENSG00000137868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBN1 / Stra6l / Stimulated by retinoic acid 6 protein-like ENSMUSG0000002832719


Protein motifs (from Interpro)
Interpro ID Name
 IPR026612  Receptor for retinol uptake STRA6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0030540 female genitalia development IEA
 biological_processGO:0034633 retinol transport IEA
 biological_processGO:0035461 vitamin transmembrane transport IEA
 biological_processGO:0042297 vocal learning IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0043585 nose morphogenesis IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048520 positive regulation of behavior IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048745 smooth muscle tissue development IEA
 biological_processGO:0048844 artery morphogenesis IEA
 biological_processGO:0050890 cognition IEA
 biological_processGO:0050905 neuromuscular process IEA
 biological_processGO:0060322 head development IEA
 biological_processGO:0060323 head morphogenesis IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0060426 lung vasculature development IEA
 biological_processGO:0060539 diaphragm development IEA
 biological_processGO:0060900 embryonic camera-type eye formation IEA
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0061038 uterus morphogenesis IEA
 biological_processGO:0061143 alveolar primary septum development IEA
 biological_processGO:0061156 pulmonary artery morphogenesis IEA
 biological_processGO:0061205 paramesonephric duct development IEA
 biological_processGO:0097070 ductus arteriosus closure IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0034632 retinol transmembrane transporter activity IEA
 molecular_functionGO:0090482 vitamin transmembrane transporter activity IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-HPV16E6E7,-luc)#Mspi/0,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ

 MP:0000439 enlarged skull 
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-HPV16E6E7,-luc)#Mspi/0,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-88H/Oca2p
Genetic Background: involves: 101/H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Oca2p-88H/Oca2p
Genetic Background: involves: 101/H

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(CAG-HPV16E6E7,-luc)#Mspi/0,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * FVB/N * FVB/NJ

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oca2p-88H/Oca2p
Genetic Background: involves: 101/H

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0002698 abnormal sclera morphology "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Oca2p-88H/Oca2p
Genetic Background: involves: 101/H

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0004185 abnormal adipocyte glucose uptake "anomaly in the ability of adipocytes to take in glucose" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0006237 abnormal choroid vasculature "malformation of the blood vessels of the choroid" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cysltr1tm1Ykn/Cysltr1tm1Ykn,Cysltr2tm1Ykn/Cysltr2tm1Ykn,Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010192 abnormal retinal melanin granule morphology "any structural anomaly of the pigment particles in the retina" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010711 persistent hyperplastic primary vitreous "persistence of the embryonic fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

 MP:0011232 abnormal vitamin A level "any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011233 abnormal vitamin A metabolism "altered ability to metabolize any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet" [GO:0035238]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic Background: B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw

 MP:0011996 abnormal retinal inner nuclear layer thickness "anomaly in the thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:csmith]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Stra6tm1.1Jvli/Stra6tm1.1Jvli
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Stra6tm1Jvli/Stra6tm1Jvli
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr