ENSMUSG00000032383


Mus musculus

Features
Gene ID: ENSMUSG00000032383
  
Biological name :Ppib
  
Synonyms : P24369 / peptidylprolyl isomerase B / Ppib
  
Possible biological names infered from orthology : P23284
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 66060222
Gene end: 66066623
  
Corresponding Affymetrix probe sets: 10586477 (MoGene1.0st)   1437649_x_at (Mouse Genome 430 2.0 Array)   1450911_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034947
NCBI entrez gene - 19035     See in Manteia.
MGI - MGI:97750
RefSeq - NM_011149
RefSeq Peptide - NP_035279
swissprot - P24369
swissprot - Q9DCY1
Ensembl - ENSMUSG00000032383
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppibENSDARG00000092798Danio rerio
 PPIBENSGALG00000002210Gallus gallus
 PPIBENSG00000166794Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppic / P30412 / peptidylprolyl isomerase C / P45877*ENSMUSG0000002453863
Gm7879 / Q9D868 / Peptidyl-prolyl cis-trans isomerase H / PPIH* / O43447* / peptidylprolyl isomerase H*ENSMUSG0000003303645
Ppih / Q9D868 / Peptidyl-prolyl cis-trans isomerase H ENSMUSG0000006028843
Ppwd1 / Q8CEC6 / Peptidylprolyl isomerase domain and WD repeat-containing protein 1 / Q96BP3* / peptidylprolyl isomerase domain and WD repeat containing 1*ENSMUSG0000002171338
Ppil1 / Q9D0W5 / Peptidyl-prolyl cis-trans isomerase-like 1 / Q9Y3C6* / peptidylprolyl isomerase like 1*ENSMUSG0000002400737
Ppil2 / Q9D787 / Mus musculus peptidylprolyl isomerase (cyclophilin)-like 2 (Ppil2), transcript variant 4, mRNA. / Q13356* / peptidylprolyl isomerase like 2*ENSMUSG0000002277136
Ppil6 / peptidylprolyl isomerase like 6 / Q8IXY8*ENSMUSG0000007845134
Ppil3 / Q9D6L8 / Peptidyl-prolyl cis-trans isomerase-like 3 / Q9H2H8* / peptidylprolyl isomerase like 3*ENSMUSG0000002603531
Ppil4 / Q9CXG3 / Peptidyl-prolyl cis-trans isomerase-like 4 / Q8WUA2* / peptidylprolyl isomerase like 4*ENSMUSG0000001575731
Cwc27 / Q3TKY6 / Peptidyl-prolyl cis-trans isomerase CWC27 homolog / Q6UX04* / CWC27 spliceosome associated protein homolog*ENSMUSG0000002171530


Protein motifs (from Interpro)
Interpro ID Name
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization ISS
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0044794 positive regulation by host of viral process IEA
 biological_processGO:0044829 positive regulation by host of viral genome replication IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding ISS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS
 molecular_functionGO:0070063 RNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005421 loose skin "condition in which the skin hangs in folds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013620 increased internal diameter of femur "increased cross-sectional distance that extends from one lateral edge of the femur long bone marrow cavity, through its center and to the opposite lateral edge of the bone marrow cavity through the mid point of the femur" [PMID:23197339]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013624 decreased femur compact bone thickness "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013626 decreased femur yield load "decrease in load (N) on the femur at which elastic deformation ends" [MGI:jwhite]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013633 decreased femur maximal load "decrease in the maximal load (N) sustained by the femur" [MGI:jwhite]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013638 decreased femur stiffness "decrease in material stiffness (N/mm) during elastic deformation in the femur" [MGI:jwhite]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
Show

Allelic Composition: PpibGt(RST139)Byg/PpibGt(RST139)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020254 decreased collagen level "decreased level of the main structural protein of the various connective tissues in animals" [GOC:NV, PMID:11704682]
Show

Allelic Composition: Whrntm1Tili/Whrntm1Tili
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028641 P3h1 / Q3V1T4 / Prolyl 3-hydroxylase 1 / Q32P28*  / complex
 ENSMUSG00000032431 Crtap / Q9CYD3 / Cartilage-associated protein / O75718*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr