ENSMUSG00000032431


Mus musculus

Features
Gene ID: ENSMUSG00000032431
  
Biological name :Crtap
  
Synonyms : Cartilage-associated protein / Crtap / Q9CYD3
  
Possible biological names infered from orthology : O75718
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 114375134
Gene end: 114390675
  
Corresponding Affymetrix probe sets: 10597413 (MoGene1.0st)   1448592_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081941
NCBI entrez gene - 56693     See in Manteia.
MGI - MGI:1891221
RefSeq - NM_019922
RefSeq Peptide - NP_064306
swissprot - Q9CYD3
Ensembl - ENSMUSG00000032431
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crtapENSDARG00000018010Danio rerio
 CRTAPENSGALG00000034163Gallus gallus
 CRTAPENSG00000170275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P3h4 / Q8K2B0 / Endoplasmic reticulum protein SC65 / Q92791* / prolyl 3-hydroxylase family member 4 (non-enzymatic)*ENSMUSG0000000693154
P3h1 / Q3V1T4 / Prolyl 3-hydroxylase 1 / Q32P28*ENSMUSG0000002864133
P3h2 / Q8CG71 / Prolyl 3-hydroxylase 2 / Q8IVL5*ENSMUSG0000003816830
P3h3 / Q8CG70 / Prolyl 3-hydroxylase 3 / Q8IVL6*ENSMUSG0000002319127


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR033212  Cartilage-associated protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IEP
 biological_processGO:0018400 peptidyl-proline hydroxylation to 3-hydroxy-L-proline IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0061077 chaperone-mediated protein folding ISS
 biological_processGO:1901874 negative regulation of post-translational protein modification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0032991 protein-containing complex ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Rettm3Cos/Rettm3Cos
Genetic Background: involves: 129S1/Sv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028641 P3h1 / Q3V1T4 / Prolyl 3-hydroxylase 1 / Q32P28*  / complex
 ENSMUSG00000032383 Ppib / P24369 / peptidylprolyl isomerase B / P23284*  / complex






 

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