ENSMUSG00000038168


Mus musculus

Features
Gene ID: ENSMUSG00000038168
  
Biological name :P3h2
  
Synonyms : P3h2 / Prolyl 3-hydroxylase 2 / Q8CG71
  
Possible biological names infered from orthology : Q8IVL5
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B1
Gene start: 25959288
Gene end: 26105784
  
Corresponding Affymetrix probe sets: 10438753 (MoGene1.0st)   1436178_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038056
NCBI entrez gene - 210530     See in Manteia.
MGI - MGI:2146663
RefSeq - NM_173379
RefSeq Peptide - NP_775555
swissprot - Q8CG71
Ensembl - ENSMUSG00000038168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p3h2ENSDARG00000103026Danio rerio
 P3H2ENSGALG00000040866Gallus gallus
 P3H2ENSG00000090530Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P3h1 / Q3V1T4 / Prolyl 3-hydroxylase 1 / Q32P28*ENSMUSG0000002864148
P3h3 / Q8CG70 / Prolyl 3-hydroxylase 3 / Q8IVL6*ENSMUSG0000002319140
P3h4 / Q8K2B0 / Endoplasmic reticulum protein SC65 / Q92791* / prolyl 3-hydroxylase family member 4 (non-enzymatic)*ENSMUSG0000000693118
Crtap / Q9CYD3 / Cartilage-associated protein / O75718*ENSMUSG0000003243117


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0032963 collagen metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019797 procollagen-proline 3-dioxygenase activity ISO
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr