ENSMUSG00000023191


Mus musculus

Features
Gene ID: ENSMUSG00000023191
  
Biological name :P3h3
  
Synonyms : P3h3 / Prolyl 3-hydroxylase 3 / Q8CG70
  
Possible biological names infered from orthology : Q8IVL6
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124841089
Gene end: 124857752
  
Corresponding Affymetrix probe sets: 10547869 (MoGene1.0st)   1449531_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116338
Ensembl peptide - ENSMUSP00000023958
NCBI entrez gene - 14789     See in Manteia.
MGI - MGI:1315208
RefSeq - NM_013534
RefSeq - XM_017321394
RefSeq Peptide - NP_038562
swissprot - D6RHQ3
swissprot - Q8CG70
Ensembl - ENSMUSG00000023191
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p3h3ENSDARG00000057879Danio rerio
 ENSGALG00000014490Gallus gallus
 P3H3ENSG00000110811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P3h1 / Q3V1T4 / Prolyl 3-hydroxylase 1 / Q32P28*ENSMUSG0000002864141
P3h2 / Q8CG71 / Prolyl 3-hydroxylase 2 / Q8IVL5*ENSMUSG0000003816839
P3h4 / Q8K2B0 / Endoplasmic reticulum protein SC65 / Q92791* / prolyl 3-hydroxylase family member 4 (non-enzymatic)*ENSMUSG0000000693115
Crtap / Q9CYD3 / Cartilage-associated protein / O75718*ENSMUSG0000003243115


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0017185 peptidyl-lysine hydroxylation IMP
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0032963 collagen metabolic process IBA
 biological_processGO:0032964 collagen biosynthetic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:1902494 catalytic complex IMP
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019797 procollagen-proline 3-dioxygenase activity IBA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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