ENSG00000110811


Homo sapiens

Features
Gene ID: ENSG00000110811
  
Biological name :P3H3
  
Synonyms : P3H3 / prolyl 3-hydroxylase 3 / Q8IVL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 6828410
Gene end: 6839851
  
Corresponding Affymetrix probe sets: 204854_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478600
NCBI entrez gene - 10536     See in Manteia.
OMIM - 610342
RefSeq - NM_014262
RefSeq Peptide - NP_055077
swissprot - Q8IVL6
Ensembl - ENSG00000110811
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 p3h3ENSDARG00000057879Danio rerio
 ENSGALG00000014490Gallus gallus
 P3h3ENSMUSG00000023191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P3H1 / Q32P28 / prolyl 3-hydroxylase 1ENSG0000011738542
P3H2 / Q8IVL5 / prolyl 3-hydroxylase 2ENSG0000009053041
P3H4 / Q92791 / prolyl 3-hydroxylase family member 4 (non-enzymatic)ENSG0000014169615
CRTAP / O75718 / cartilage associated proteinENSG0000017027514


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit
 IPR011990  Tetratricopeptide-like helical domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0017185 peptidyl-lysine hydroxylation IEA
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0032963 collagen metabolic process IBA
 biological_processGO:0032964 collagen biosynthetic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:1902494 catalytic complex IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019797 procollagen-proline 3-dioxygenase activity IBA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Collagen biosynthesis and modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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