ENSMUSG00000021715


Mus musculus

Features
Gene ID: ENSMUSG00000021715
  
Biological name :Cwc27
  
Synonyms : Cwc27 / Peptidyl-prolyl cis-trans isomerase CWC27 homolog / Q3TKY6
  
Possible biological names infered from orthology : CWC27 spliceosome associated protein homolog / Q6UX04
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 104631140
Gene end: 104817142
  
Corresponding Affymetrix probe sets: 10411927 (MoGene1.0st)   1426455_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022228
Ensembl peptide - ENSMUSP00000119076
NCBI entrez gene - 67285     See in Manteia.
MGI - MGI:1914535
RefSeq - XM_017315574
RefSeq - NM_026072
RefSeq - XM_011244690
RefSeq - XM_011244691
RefSeq - XM_017315573
RefSeq Peptide - NP_080348
swissprot - Q3TKY6
swissprot - D3Z2U3
Ensembl - ENSMUSG00000021715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cwc27ENSDARG00000043727Danio rerio
 CWC27ENSGALG00000014747Gallus gallus
 CWC27ENSG00000153015Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppil4 / Q9CXG3 / Peptidyl-prolyl cis-trans isomerase-like 4 / Q8WUA2* / peptidylprolyl isomerase like 4*ENSMUSG0000001575722
Ppil2 / Q9D787 / Mus musculus peptidylprolyl isomerase (cyclophilin)-like 2 (Ppil2), transcript variant 4, mRNA. / Q13356* / peptidylprolyl isomerase like 2*ENSMUSG0000002277121
Ppwd1 / Q8CEC6 / Peptidylprolyl isomerase domain and WD repeat-containing protein 1 / Q96BP3* / peptidylprolyl isomerase domain and WD repeat containing 1*ENSMUSG0000002171316
Ppil1 / Q9D0W5 / Peptidyl-prolyl cis-trans isomerase-like 1 / Q9Y3C6* / peptidylprolyl isomerase like 1*ENSMUSG0000002400715
Ppil3 / Q9D6L8 / Peptidyl-prolyl cis-trans isomerase-like 3 / Q9H2H8* / peptidylprolyl isomerase like 3*ENSMUSG0000002603515
Ppic / P30412 / peptidylprolyl isomerase C / P45877*ENSMUSG0000002453814
Ppib / P24369 / peptidylprolyl isomerase B / P23284*ENSMUSG0000003238314
Ppih / Q9D868 / Peptidyl-prolyl cis-trans isomerase H ENSMUSG0000006028814
Gm7879 / Q9D868 / Peptidyl-prolyl cis-trans isomerase H / PPIH* / O43447* / peptidylprolyl isomerase H*ENSMUSG0000003303613
Ppil6 / peptidylprolyl isomerase like 6 / Q8IXY8*ENSMUSG0000007845112


Protein motifs (from Interpro)
Interpro ID Name
 IPR002130  Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
 IPR020892  Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
 IPR024936  Cyclophilin-type peptidyl-prolyl cis-trans isomerase
 IPR029000  Cyclophilin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006457 protein folding IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0016853 isomerase activity IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0010865 prenatal growth retardation "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

Allelic Composition: Cwc27tm1Lex/Cwc27tm1Lex
Genetic Background: B6;129S5-Cwc27tm1Lex/Mmucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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