MP:0000576 | clubbed feet | "congenital deformation of the feet; foot is plantarflexed, inverted and adducted" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Drc3m6Bei/Drc3m6Bei,Rgs4tm1Dgen/Rgs4+ Genetic Background: involves: 129P2/OlaHsd * A/J * C57BL/6
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MP:0000780 | abnormal corpus callosum morphology | "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0000781 | reduced size of corpus callosum | "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0000830 | abnormal diencephalon morphology | "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0000832 | abnormal thalamus morphology | "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0000897 | abnormal midbrain | "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP*)1Slp/0 Genetic Background: B6.Cg-Mycbp2mgln Tg(Isl1-EGFP*)1Slp
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MP:0000940 | abnormal motor neuron innervation | "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: KitW-2Btlr/Kit+ Genetic Background: involves: C3H/HeN * C57BL/6
Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP)2Slp/0 Genetic Background: involves: C3H * C57BL/6 * DBA/2J
Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Mnx1-GFP)1Slp/0 Genetic Background: involves: C3H * C57BL/6 * DBA/2J
Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP*)1Slp/0 Genetic Background: B6.Cg-Mycbp2mgln Tg(Isl1-EGFP*)1Slp
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MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb Genetic Background: involves: 129P2/OlaHsd
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MP:0000965 | abnormal sensory neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP*)1Slp/0 Genetic Background: B6.Cg-Mycbp2mgln Tg(Isl1-EGFP*)1Slp
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MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
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Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP*)1Slp/0 Genetic Background: B6.Cg-Mycbp2mgln Tg(Isl1-EGFP*)1Slp
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MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S1/Sv * C57BL/6
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MP:0001077 | abnormal spinal nerve morphology | "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP*)1Slp/0 Genetic Background: B6.Cg-Mycbp2mgln Tg(Isl1-EGFP*)1Slp
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MP:0001078 | abnormal phrenic nerve | "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm,Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm,Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm,Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm,Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ednrbs-24Pub/Ednrb+,Mycbp2m274-4Tpo/Mycbp2+ Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
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MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0002279 | abnormal diaphragm morphology | "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0002961 | abnormal axon guidance | "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0003241 | loss of cortex neurons | "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0003632 | abnormal nervous system morphology | |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Ednrbs-15DttMb/Ednrb+,Mycbp2tm1.1Adia/Mycbp2+ Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6 * FVB/N
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MP:0003651 | abnormal axon outgrowth | "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121] |
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Allelic Composition: Mycbp2mgln/Mycbp2mgln,Tg(Isl1-EGFP*)1Slp/0 Genetic Background: B6.Cg-Mycbp2mgln Tg(Isl1-EGFP*)1Slp
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MP:0003998 | decreased thermal nociceptive threshold | "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb Genetic Background: involves: 129P2/OlaHsd
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MP:0004077 | abnormal striatum morphology | "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0004082 | abnormal habenula development | "anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0004101 | abnormal brain interneuron morphology | "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0004103 | abnormal ventral striatum morphology | "any structural abnormality of the regions of the nucleus accumbens and some nuclei of the olfactory tubercule that lie ventral to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0004165 | abnormal lateral geniculate nucleus morphology | "any malformation or absence of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
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MP:0008128 | abnormal brain internal capsule morphology | "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0008129 | absent brain internal capsule | "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Map3k12Gt(RRN366)Byg/Map3k12Gt(RRN366)Byg,Mycbp2tm1.1Adia/Mycbp2tm1.1Adia Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0008227 | absent anterior commissure | "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0008458 | abnormal cortical ventricular zone morphology | "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mycbp2m7Bei/Mycbp2m7Bei,Cntn2tm1Furl/Cntn2+ Genetic Background: involves: 129S1/Sv * A/J * C57BL/6
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MP:0009674 | decreased birth weight | "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"] |
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Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm,Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm,Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gcnt1tm1Jxm/Gcnt1tm1Jxm,Gcnt3tm1.1Jxm/Gcnt3tm1.1Jxm,Gcnt4tm1.1Jxm/Gcnt4tm1.1Jxm Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010769 | abnormal survival | "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb Genetic Background: involves: 129P2/OlaHsd
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N
Allelic Composition: Mycbp2m274-4Tpo/Mycbp2m274-4Tpo Genetic Background: involves: C57BL/6J * SSL/LeJ
Allelic Composition: Ednrbs-24Pub/Ednrb+,Mycbp2m274-4Tpo/Mycbp2+ Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Mycbp2tm1Adia/Mycbp2tm1Adia Genetic Background: involves: 129S1/Sv * C57BL/6
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