ENSMUSG00000033105


Mus musculus

Features
Gene ID: ENSMUSG00000033105
  
Biological name :Lss
  
Synonyms : lanosterol synthase / Lss / Q8BLN5
  
Possible biological names infered from orthology : P48449
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 76531588
Gene end: 76557138
  
Corresponding Affymetrix probe sets: 10364194 (MoGene1.0st)   1420013_s_at (Mouse Genome 430 2.0 Array)   1420014_at (Mouse Genome 430 2.0 Array)   1426913_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046856
Ensembl peptide - ENSMUSP00000125575
NCBI entrez gene - 16987     See in Manteia.
MGI - MGI:1336155
RefSeq - XM_017313817
RefSeq - NM_146006
RefSeq - XM_006513283
RefSeq - XM_006513284
RefSeq Peptide - NP_666118
swissprot - F7BJL0
swissprot - Q8BLN5
Ensembl - ENSMUSG00000033105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lssENSDARG00000061274Danio rerio
 LSSENSGALG00000006198Gallus gallus
 LSSENSG00000160285Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002365  Terpene synthase, conserved site
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR018333  Squalene cyclase
 IPR032696  Squalene cyclase, C-terminal
 IPR032697  Squalene cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process ISO
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0031647 regulation of protein stability IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000250 lanosterol synthase activity ISO
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0016866 intramolecular transferase activity IEA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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