ENSMUSG00000033237


Mus musculus

Features
Gene ID: ENSMUSG00000033237
  
Biological name :Arid2
  
Synonyms : Arid2 / AT-rich interactive domain-containing protein 2 / E9Q7E2
  
Possible biological names infered from orthology : AT-rich interaction domain 2 / Q68CP9
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 96287518
Gene end: 96404992
  
Corresponding Affymetrix probe sets: 10426507 (MoGene1.0st)   1426525_at (Mouse Genome 430 2.0 Array)   1432483_at (Mouse Genome 430 2.0 Array)   1434506_at (Mouse Genome 430 2.0 Array)   1454990_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135829
Ensembl peptide - ENSMUSP00000093969
NCBI entrez gene - 77044     See in Manteia.
MGI - MGI:1924294
RefSeq - NM_175251
RefSeq Peptide - NP_780460
swissprot - E9Q7E2
swissprot - Q9D982
Ensembl - ENSMUSG00000033237
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arid2ENSDARG00000007413Danio rerio
 ARID2ENSGALG00000033074Gallus gallus
 ARID2ENSG00000189079Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001606  ARID DNA-binding domain
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR011989  Armadillo-like helical
 IPR013087  Zinc finger C2H2-type
 IPR016024  Armadillo-type fold
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily
 IPR036431  ARID DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006337 nucleosome disassembly IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0042592 homeostatic process IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048568 embryonic organ development IMP
 biological_processGO:0060038 cardiac muscle cell proliferation IMP
 biological_processGO:0060982 coronary artery morphogenesis IMP
 biological_processGO:0072358 cardiovascular system development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex ISO
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002745 abnormal atrioventricular valve morphology "malformation of the valves that gate the flow of blood from the atria into the ventricles" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010419 inlet ventricular septal defect "abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves" [http://emedicine.medscape.com]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011395 decreased fetal cardiomyocyte proliferation "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
Show

Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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