Manteia - Molecule gene

ENSMUSG00000033400

Mus musculus

Features

Gene ID:	ENSMUSG00000033400

Biological name :	Agl

Synonyms :	Agl / amylo-1,6-glucosidase, 4-alpha-glucanotransferase

Possible biological names infered from orthology :	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase / P35573

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	G1
Gene start:	116739999
Gene end:	116808166

Corresponding Affymetrix probe sets:	10501699 (MoGene1.0st) 1429083_at (Mouse Genome 430 2.0 Array) 1431032_at (Mouse Genome 430 2.0 Array) 1431033_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124149 Ensembl peptide - ENSMUSP00000143582 Ensembl peptide - ENSMUSP00000125246 Ensembl peptide - ENSMUSP00000124840 Ensembl peptide - ENSMUSP00000044012 Ensembl peptide - ENSMUSP00000123877 Ensembl peptide - ENSMUSP00000123985 NCBI entrez gene - 77559 See in Manteia. MGI - MGI:1924809 RefSeq - NM_001081326 RefSeq - XM_006502287 RefSeq - XM_011240280 RefSeq Peptide - NP_001074795 swissprot - E0CYU6 swissprot - F8VPN4 swissprot - E0CX86 swissprot - A0A0G2JGI9 swissprot - F6XXE6 swissprot - F7CSZ6 Ensembl - ENSMUSG00000033400

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
agla	ENSDARG00000103811	Danio rerio
aglb	ENSDARG00000100352	Danio rerio
LO018627.1	ENSDARG00000106630	Danio rerio
AGL	ENSGALG00000005407	Gallus gallus
AGL	ENSG00000162688	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR006421	Glycogen debranching enzyme, metazoa
IPR008928	Six-hairpin glycosidase superfamily
IPR010401	Glycogen debranching enzyme
IPR017853	Glycoside hydrolase superfamily
IPR029436	Eukaryotic glycogen debranching enzyme, N-terminal domain
IPR032788	Glycogen debranching enzyme, central domain
IPR032790	Glycogen debranching enzyme, C-terminal
IPR032792	Glycogen debranching enzyme, glucanotransferase domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0005977	glycogen metabolic process	IDA
biological_process	GO:0005978	glycogen biosynthetic process	IEA
biological_process	GO:0005980	glycogen catabolic process	IBA
biological_process	GO:0007584	response to nutrient	IEA
biological_process	GO:0009725	response to hormone	IEA
biological_process	GO:0051384	response to glucocorticoid	IEA
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0016234	inclusion body	IDA
cellular_component	GO:0016529	sarcoplasmic reticulum	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0004133	glycogen debranching enzyme activity	IDA
molecular_function	GO:0004134	4-alpha-glucanotransferase activity	IBA
molecular_function	GO:0004135	amylo-alpha-1,6-glucosidase activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0030246	carbohydrate binding	IEA
molecular_function	GO:0030247	polysaccharide binding	IMP
molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	IMP

Pathways (from Reactome)

Pathway description

Neutrophil degranulation

Glycogen breakdown (glycogenolysis)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0000747	muscle weakness	"loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001304	cataracts	"complete or partial opacity of the lens" [J:65031]	Show Allelic Composition: Adipor1^{tm1b(EUCOMM)Hmgu}/Adipor1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Adipor1^{tm1b(EUCOMM)Hmgu}/H
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0004357	long tibia	"increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Adipor1^{tm1b(EUCOMM)Hmgu}/Adipor1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Adipor1^{tm1b(EUCOMM)Hmgu}/H
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0005440	increased glycogen level	"greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0005573	increased breathing frequency	"greater than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010090	increased circulating creatine kinase level	"an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010400	increased liver glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010401	increased skeletal muscle glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Adipor1^{tm1b(EUCOMM)Hmgu}/Adipor1^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Adipor1^{tm1b(EUCOMM)Hmgu}/H
MP:0012106	impaired exercise endurance	"impaired performance during controlled physical activity" [MGI:smb]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0013278	decreased fasted circulating glucose level	"reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj
MP:0014071	increased cardiac muscle glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Agl^{tm1a(EUCOMM)Wtsi}/Agl^{tm1a(EUCOMM)Wtsi} Genetic Background: involves: C57BL/6N
MP:0014074	increased brain glycogen level	"greater than the normal concentration of a readily converted carbohydrate reserve in brain" [MGI:Anna]	Show Allelic Composition: Fgf10^tm1Ska/Fgf10⁺,Fgf8^tm1Moon/Fgf8^tm1Moon,Mesp1^tm2(cre)Ysa/Mesp1⁺ Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr