ENSMUSG00000033685


Mus musculus

Features
Gene ID: ENSMUSG00000033685
  
Biological name :Ucp2
  
Synonyms : P70406 / Ucp2 / uncoupling protein 2 (mitochondrial, proton carrier)
  
Possible biological names infered from orthology : P55851 / uncoupling protein 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 100493337
Gene end: 100502020
  
Corresponding Affymetrix probe sets: 10555389 (MoGene1.0st)   1448188_at (Mouse Genome 430 2.0 Array)   1459740_s_at (Mouse Genome 430 2.0 Array)   1459741_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115598
Ensembl peptide - ENSMUSP00000146337
Ensembl peptide - ENSMUSP00000120967
Ensembl peptide - ENSMUSP00000115953
Ensembl peptide - ENSMUSP00000115648
NCBI entrez gene - 22228     See in Manteia.
MGI - MGI:109354
RefSeq - XM_006507579
RefSeq - NM_011671
RefSeq Peptide - NP_035801
swissprot - D3YZE5
swissprot - D3YZG5
swissprot - A0A140LHA5
swissprot - P70406
swissprot - Q549J5
swissprot - D3YXM5
Ensembl - ENSMUSG00000033685
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ucp2ENSDARG00000043154Danio rerio
 UCP2ENSG00000175567Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ucp3 / P56501 / uncoupling protein 3 (mitochondrial, proton carrier) / P55916* / uncoupling protein 3*ENSMUSG0000003294273
Ucp1 / P12242 / uncoupling protein 1 (mitochondrial, proton carrier) / P25874* / uncoupling protein 1*ENSMUSG0000003171057
Q9Z2B2 / Slc25a14 / Mus musculus solute carrier family 25 (mitochondrial carrier, brain), member 14 (Slc25a14), transcript variant 6, mRNA. / O95258* / solute carrier family 25 member 14*ENSMUSG0000003110536
Q9CR58 / Slc25a30 / solute carrier family 25, member 30 / Q5SVS4*ENSMUSG0000002200336
Q9CR62 / Slc25a11 / solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 / Q02978* / solute carrier family 25 member 11*ENSMUSG0000001460633
Slc25a27 / solute carrier family 25, member 27 / O95847*ENSMUSG0000002391233
Q9QZD8 / Slc25a10 / solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 / Q9UBX3* / AC139530.2* / solute carrier family 25 member 10*ENSMUSG0000002579231


Protein motifs (from Interpro)
Interpro ID Name
 IPR002030  Mitochondrial carrier UCP-like
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000303 response to superoxide IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006839 mitochondrial transport IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009409 response to cold IBA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IMP
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:1990542 mitochondrial transmembrane transport IBA
 biological_processGO:1990845 adaptive thermogenesis IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0017077 oxidative phosphorylation uncoupler activity IBA


Pathways (from Reactome)
Pathway description
The fatty acid cycling model
The proton buffering model


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tex11tm1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: C57BL/6-Tnfrsf1atm1Imx

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: C57BL/6-Tnfrsf1atm1Imx

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: C57BL/6-Tnfrsf1atm1Imx

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tex11tm1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/NJ

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tex11tm1Jw/Y,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

Allelic Composition: Tg(Npy-MAPT/Sapphire)1Rck/?,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tg(Pomc-MAPT/Topaz)1Rck/0,Ucp2Gt(S20-3G1)Sor/Ucp2Gt(S20-3G1)Sor
Genetic Background: involves: C57BL/6 * CBA

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0006039 decreased mitochondrial proliferation "less than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008413 decreased cellular sensitivity to oxidative stress "reduced incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0009786 decreased susceptibility to infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gfra1tm1Bjh/Gfra1tm1Bjh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * CD-1) or (involves: 129S1/Sv * 129X1/SvJ * Swiss Black)

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht,Cdk5r2tm1Lht/Cdk5r2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Myo5ad/Myo5a+,Rgsc80/Rgsc80+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr