ENSMUSG00000031710


Mus musculus

Features
Gene ID: ENSMUSG00000031710
  
Biological name :Ucp1
  
Synonyms : P12242 / Ucp1 / uncoupling protein 1 (mitochondrial, proton carrier)
  
Possible biological names infered from orthology : P25874 / uncoupling protein 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 83290352
Gene end: 83298452
  
Corresponding Affymetrix probe sets: 10573152 (MoGene1.0st)   1418197_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034146
NCBI entrez gene - 22227     See in Manteia.
MGI - MGI:98894
RefSeq - NM_009463
RefSeq Peptide - NP_033489
swissprot - P12242
Ensembl - ENSMUSG00000031710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ucp1ENSDARG00000023151Danio rerio
 UCP1ENSG00000109424Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ucp2 / P70406 / uncoupling protein 2 (mitochondrial, proton carrier) / P55851* / uncoupling protein 2*ENSMUSG0000003368557
Ucp3 / P56501 / uncoupling protein 3 (mitochondrial, proton carrier) / P55916* / uncoupling protein 3*ENSMUSG0000003294254
Q9CR58 / Slc25a30 / solute carrier family 25, member 30 / Q5SVS4*ENSMUSG0000002200333
Q9Z2B2 / Slc25a14 / Mus musculus solute carrier family 25 (mitochondrial carrier, brain), member 14 (Slc25a14), transcript variant 6, mRNA. / O95258* / solute carrier family 25 member 14*ENSMUSG0000003110532
Q9CR62 / Slc25a11 / solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 / Q02978* / solute carrier family 25 member 11*ENSMUSG0000001460631
Slc25a27 / solute carrier family 25, member 27 / O95847*ENSMUSG0000002391230
Q9QZD8 / Slc25a10 / solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 / Q9UBX3* / AC139530.2* / solute carrier family 25 member 10*ENSMUSG0000002579229


Protein motifs (from Interpro)
Interpro ID Name
 IPR002030  Mitochondrial carrier UCP-like
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002024 diet induced thermogenesis IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006839 mitochondrial transport IBA
 biological_processGO:0009266 response to temperature stimulus IMP
 biological_processGO:0009409 response to cold IBA
 biological_processGO:0031667 response to nutrient levels IMP
 biological_processGO:0032870 cellular response to hormone stimulus IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0050873 brown fat cell differentiation IEP
 biological_processGO:0071398 cellular response to fatty acid IDA
 biological_processGO:1902600 proton transmembrane transport IDA
 biological_processGO:1903426 regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1990542 mitochondrial transmembrane transport IMP
 biological_processGO:1990845 adaptive thermogenesis IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005740 mitochondrial envelope IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017077 oxidative phosphorylation uncoupler activity IMP
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0032555 purine ribonucleotide binding IDA
 molecular_functionGO:0036041 long-chain fatty acid binding IDA
 molecular_functionGO:1901612 cardiolipin binding ISS


Pathways (from Reactome)
Pathway description
The fatty acid cycling model
The proton buffering model


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: 129S1.Cg-Ucptm1Kz

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grin1tm2Stl/Grin1tm2Stl,Tg(Actb-tTA)1Jzt/0,Tg(Camk2a-cre)62Jzt/0,Tg(tetO-Grin1/GFP)1Jzt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: 129S1.Cg-Ucptm1Kz

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz,Ucp3tm1Rei/Ucp3tm1Rei
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: 129S1.Cg-Ucptm1Kz

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: (129S1.Cg-Ucptm1Kz x B6.Cg-Ucptm1Kz)F1

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

Allelic Composition: Lepob/Lepob,Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Unc13atm1Bros/Unc13atm1Bros
Genetic Background: Not Specified

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: 129S1.Cg-Ucptm1Kz

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: B6.Cg-Ucptm1Kz

Allelic Composition: Lepob/Lepob,Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cfap157tm1b(EUCOMM)Hmgu/Cfap157tm1b(EUCOMM)Hmgu
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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