ENSG00000109424


Homo sapiens

Features
Gene ID: ENSG00000109424
  
Biological name :UCP1
  
Synonyms : P25874 / UCP1 / uncoupling protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q31.1
Gene start: 140559434
Gene end: 140568805
  
Corresponding Affymetrix probe sets: 221384_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262999
NCBI entrez gene - 7350     See in Manteia.
OMIM - 113730
RefSeq - XM_011532228
RefSeq - NM_021833
RefSeq - XM_005263206
RefSeq Peptide - NP_068605
swissprot - P25874
Ensembl - ENSG00000109424
  
Related genetic diseases (OMIM): 601665 - {Obesity, susceptibility to}, 601665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ucp1ENSDARG00000023151Danio rerio
 Ucp1ENSMUSG00000031710Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UCP2 / P55851 / uncoupling protein 2ENSG0000017556758
UCP3 / P55916 / uncoupling protein 3ENSG0000017556458
Q5SVS4 / SLC25A30 / solute carrier family 25 member 30ENSG0000017403233
O95258 / SLC25A14 / solute carrier family 25 member 14ENSG0000010207833
Q02978 / SLC25A11 / solute carrier family 25 member 11ENSG0000010852831
AC139530.2ENSG0000026266030
O95847 / SLC25A27 / solute carrier family 25 member 27ENSG0000015329129
Q9UBX3 / SLC25A10 / solute carrier family 25 member 10ENSG0000018304821


Protein motifs (from Interpro)
Interpro ID Name
 IPR002030  Mitochondrial carrier UCP-like
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002024 diet induced thermogenesis IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006839 mitochondrial transport IBA
 biological_processGO:0009266 response to temperature stimulus IEA
 biological_processGO:0009409 response to cold IBA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:1903426 regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1990542 mitochondrial transmembrane transport IEA
 biological_processGO:1990845 adaptive thermogenesis IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005740 mitochondrial envelope IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0017077 oxidative phosphorylation uncoupler activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IDA
 molecular_functionGO:0032555 purine ribonucleotide binding IEA
 molecular_functionGO:0036041 long-chain fatty acid binding IEA
 molecular_functionGO:1901612 cardiolipin binding ISS


Pathways (from Reactome)
Pathway description
The fatty acid cycling model
The proton buffering model


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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