ENSG00000175564


Homo sapiens

Features
Gene ID: ENSG00000175564
  
Biological name :UCP3
  
Synonyms : P55916 / UCP3 / uncoupling protein 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 74000281
Gene end: 74009435
  
Corresponding Affymetrix probe sets: 207349_s_at (Human Genome U133 Plus 2.0 Array)   219827_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445279
Ensembl peptide - ENSP00000323740
Ensembl peptide - ENSP00000392143
NCBI entrez gene - 7352     See in Manteia.
OMIM - 602044
RefSeq - NM_022803
RefSeq - NM_003356
RefSeq Peptide - NP_003347
RefSeq Peptide - NP_073714
swissprot - P55916
swissprot - A0A0S2Z4G5
swissprot - F5H3N5
Ensembl - ENSG00000175564
  
Related genetic diseases (OMIM): 601665 - {Obesity, severe, and type II diabetes}, 601665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UCP3ENSGALG00000017316Gallus gallus
 Ucp3ENSMUSG00000032942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UCP2 / P55851 / uncoupling protein 2ENSG0000017556772
UCP1 / P25874 / uncoupling protein 1ENSG0000010942457
Q5SVS4 / SLC25A30 / solute carrier family 25 member 30ENSG0000017403236
O95258 / SLC25A14 / solute carrier family 25 member 14ENSG0000010207835
O95847 / SLC25A27 / solute carrier family 25 member 27ENSG0000015329134
Q02978 / SLC25A11 / solute carrier family 25 member 11ENSG0000010852831
AC139530.2ENSG0000026266030
Q9UBX3 / SLC25A10 / solute carrier family 25 member 10ENSG0000018304822


Protein motifs (from Interpro)
Interpro ID Name
 IPR002030  Mitochondrial carrier UCP-like
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000303 response to superoxide IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006839 mitochondrial transport IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007585 respiratory gaseous exchange TAS
 biological_processGO:0009409 response to cold IBA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:1902600 proton transmembrane transport TAS
 biological_processGO:1990542 mitochondrial transmembrane transport IBA
 biological_processGO:1990845 adaptive thermogenesis IBA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017077 oxidative phosphorylation uncoupler activity IBA


Pathways (from Reactome)
Pathway description
The fatty acid cycling model
The proton buffering model


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr