ENSMUSG00000032942


Mus musculus

Features
Gene ID: ENSMUSG00000032942
  
Biological name :Ucp3
  
Synonyms : P56501 / Ucp3 / uncoupling protein 3 (mitochondrial, proton carrier)
  
Possible biological names infered from orthology : P55916 / uncoupling protein 3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 100472990
Gene end: 100486432
  
Corresponding Affymetrix probe sets: 10555378 (MoGene1.0st)   1420657_at (Mouse Genome 430 2.0 Array)   1420658_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102674
Ensembl peptide - ENSMUSP00000032958
NCBI entrez gene - 22229     See in Manteia.
MGI - MGI:1099787
RefSeq - NM_009464
RefSeq Peptide - NP_033490
swissprot - B2RTM2
swissprot - P56501
Ensembl - ENSMUSG00000032942
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UCP3ENSGALG00000017316Gallus gallus
 UCP3ENSG00000175564Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ucp2 / P70406 / uncoupling protein 2 (mitochondrial, proton carrier) / P55851* / uncoupling protein 2*ENSMUSG0000003368574
Ucp1 / P12242 / uncoupling protein 1 (mitochondrial, proton carrier) / P25874* / uncoupling protein 1*ENSMUSG0000003171054
Q9Z2B2 / Slc25a14 / Mus musculus solute carrier family 25 (mitochondrial carrier, brain), member 14 (Slc25a14), transcript variant 6, mRNA. / O95258* / solute carrier family 25 member 14*ENSMUSG0000003110537
Q9CR58 / Slc25a30 / solute carrier family 25, member 30 / Q5SVS4*ENSMUSG0000002200337
Slc25a27 / solute carrier family 25, member 27 / O95847*ENSMUSG0000002391235
Q9CR62 / Slc25a11 / solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 / Q02978* / solute carrier family 25 member 11*ENSMUSG0000001460633
Q9QZD8 / Slc25a10 / solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10 / Q9UBX3* / AC139530.2* / solute carrier family 25 member 10*ENSMUSG0000002579230


Protein motifs (from Interpro)
Interpro ID Name
 IPR002030  Mitochondrial carrier UCP-like
 IPR018108  Mitochondrial substrate/solute carrier
 IPR023395  Mitochondrial carrier domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000303 response to superoxide IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0006839 mitochondrial transport IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009409 response to cold IBA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:1902600 proton transmembrane transport IEA
 biological_processGO:1990542 mitochondrial transmembrane transport IBA
 biological_processGO:1990845 adaptive thermogenesis IBA
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005743 mitochondrial inner membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0017077 oxidative phosphorylation uncoupler activity IMP


Pathways (from Reactome)
Pathway description
The fatty acid cycling model
The proton buffering model


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd22tm1Eac/Cd22tm1Eac
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ucp1tm1Kz/Ucp1tm1Kz,Ucp3tm1Rei/Ucp3tm1Rei
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd22tm1Eac/Cd22tm1Eac
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Gab2tm1Hhg/Gab2tm1Hhg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ucp3tm1Rei/Ucp3tm1Rei
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd22tm1Eac/Cd22tm1Eac
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psen1tm1Jzt/Psen1tm1Jzt
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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