ENSMUSG00000033965


Mus musculus

Features
Gene ID: ENSMUSG00000033965
  
Biological name :Slc16a2
  
Synonyms : O70324 / Slc16a2 / solute carrier family 16 (monocarboxylic acid transporters), member 2
  
Possible biological names infered from orthology : P36021 / solute carrier family 16 member 2
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: D
Gene start: 103697414
Gene end: 103821983
  
Corresponding Affymetrix probe sets: 10606186 (MoGene1.0st)   1418445_at (Mouse Genome 430 2.0 Array)   1418446_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037629
NCBI entrez gene - 20502     See in Manteia.
MGI - MGI:1203732
RefSeq - NM_009197
RefSeq Peptide - NP_033223
swissprot - O70324
swissprot - Q05BA2
Ensembl - ENSMUSG00000033965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FQ311908.1ENSDARG00000098694Danio rerio
 SLC16A2ENSGALG00000007748Gallus gallus
 P36021ENSG00000147100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3U9N9 / Slc16a10 / solute carrier family 16 (monocarboxylic acid transporters), member 10 / Q8TF71* / solute carrier family 16 member 10*ENSMUSG0000001983847
Q8R0M8 / Slc16a4 / solute carrier family 16 (monocarboxylic acid transporters), member 4 / O15374* / solute carrier family 16 member 4*ENSMUSG0000002789619
Q7TM99 / Slc16a9 / solute carrier family 16 (monocarboxylic acid transporters), member 9 / Q7RTY1* / solute carrier family 16 member 9*ENSMUSG0000003776219
Q8K1C7 / Slc16a14 / solute carrier family 16 (monocarboxylic acid transporters), member 14 / Q7RTX9* / solute carrier family 16 member 14*ENSMUSG0000002622018


Protein motifs (from Interpro)
Interpro ID Name
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR030761  Monocarboxylate transporter 8
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015718 monocarboxylic acid transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070327 thyroid hormone transport ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 molecular_functionGO:0008028 monocarboxylic acid transmembrane transporter activity IBA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0015349 thyroid hormone transmembrane transporter activity ISO


Pathways (from Reactome)
Pathway description
Transport of organic anions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005135 increased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Y
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Slc16a2tm1.1Sref/Y
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Slc16a2tm1.1Sref/Slc16a2tm1.1Sref
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005469 abnormal thyroxine level "anomalous concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0005472 abnormal triiodothyronine level "aberrant concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Rbpjtm1Hon/Rbpjtm1Hon,Spentm2.1Hon/Spentm2.1Hon
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0005473 decreased triiodothyronine level "less than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005474 increased triiodothyronine level "greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Slc16a2tm1.1Sref/Y
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Slc16a2tm1.1Sref/Slc16a2tm1.1Sref
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005476 abnormal circulating triiodothyronine level "aberration in the blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

Allelic Composition: Slc16a2tm1.1Sref/Y
Genetic Background: involves: 129/Sv * 129P2/OlaHsd

Allelic Composition: Slc16a2tm1.1Sref/Slc16a2tm1.1Sref
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Slc16a2tm1Dgen/Slc16a2tm1Dgen
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0005480 increased circulating triiodothyronine level "greater than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc16a2tm1Dgen/Slc16a2tm1Dgen
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

Allelic Composition: Slc16a2tm1Dgen/Y
Genetic Background: either: (involves: C57BL/6N) or (involves: NMRI)

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * MF1

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc16a2tm1a(KOMP)Wtsi/Slc16a2tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Slc16a2tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033965 O70324 / Slc16a2 / solute carrier family 16 (monocarboxylic acid transporters), member 2 / P36021* / solute carrier family 16 member 2*  / complex






 

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