ENSMUSG00000034126


Mus musculus

Features
Gene ID: ENSMUSG00000034126
  
Biological name :Pomt2
  
Synonyms : Pomt2 / Protein O-mannosyl-transferase 2 / Q8BGQ4
  
Possible biological names infered from orthology : protein O-mannosyltransferase 2 / Q9UKY4
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D2
Gene start: 87106861
Gene end: 87147968
  
Corresponding Affymetrix probe sets: 10401713 (MoGene1.0st)   1433644_at (Mouse Genome 430 2.0 Array)   1451396_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035260
Ensembl peptide - ENSMUSP00000152370
NCBI entrez gene - 217734     See in Manteia.
MGI - MGI:2444430
RefSeq - XM_011244090
RefSeq - NM_153415
RefSeq - XM_011244088
RefSeq - XM_011244089
RefSeq Peptide - NP_700464
swissprot - Q8BGQ4
Ensembl - ENSMUSG00000034126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pomt2ENSDARG00000055027Danio rerio
 ENSGALG00000041962Gallus gallus
 POMT2ENSG00000009830Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pomt1 / Q8R2R1 / Protein O-mannosyl-transferase 1 / Q9Y6A1* / protein O-mannosyltransferase 1*ENSMUSG0000003925428


Protein motifs (from Interpro)
Interpro ID Name
 IPR003342  Glycosyl transferase family 39/83
 IPR016093  MIR motif
 IPR027005  Glycosyltransferase 39-like
 IPR032421  Protein O-mannosyl-transferase, C-terminal four TM domain
 IPR036300  Mir domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0035269 protein O-linked mannosylation IEA
 biological_processGO:0071712 ER-associated misfolded protein catabolic process IBA
 biological_processGO:0097502 mannosylation IEA
 biological_processGO:1904100 positive regulation of protein O-linked glycosylation IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000030 mannosyltransferase activity IEA
 molecular_functionGO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000815 abnormal ammon gyrus morphology "malformations of one of the two interlocking gyri of the hippocampus; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mecp2tm1.1Meg/Y
Genetic Background: B6.129-Mecp2tm1.1Meg

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003648 abnormal radial glial cell morphology "anomalous structure, number, or composition of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0003954 abnormal Reichert s membrane "aberrant structure of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm beginning at E6.0 and is secreted by the distal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mecp2tm1.1Meg/Y
Genetic Background: B6.129-Mecp2tm1.1Meg

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008030 abnormal Cajal-Retzius cell morphology "any abnormality of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pomt2tm1.1Hhu/Pomt2tm1.1Hhu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mecp2tm1.1Meg/Y
Genetic Background: B6.129-Mecp2tm1.1Meg

 MP:0012129 failure of blastocyst formation "inability to form a blastocyst from a solid ball of cells known as a morula" [MGI:anna]
Show

Allelic Composition: Gata4tm1.1Sad/Gata4tm1.1Sad,Gata6tm2.1Sad/Gata6+,Tg(Wt1-cre)1Jbeb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039952 Dag1 / Q62165 / Dystroglycan Alpha-dystroglycan Beta-dystroglycan / Q14118* / dystroglycan 1*  / reaction
 ENSMUSG00000039254 Pomt1 / Q8R2R1 / Protein O-mannosyl-transferase 1 / Q9Y6A1* / protein O-mannosyltransferase 1*  / complex






 

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