ENSMUSG00000034274


Mus musculus

Features
Gene ID: ENSMUSG00000034274
  
Biological name :Thoc5
  
Synonyms : Thoc5 / THO complex 5
  
Possible biological names infered from orthology : Q13769
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 4895320
Gene end: 4928867
  
Corresponding Affymetrix probe sets: 10373964 (MoGene1.0st)   1452672_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118940
Ensembl peptide - ENSMUSP00000045580
Ensembl peptide - ENSMUSP00000099137
NCBI entrez gene - 107829     See in Manteia.
MGI - MGI:1351333
RefSeq - NM_172438
RefSeq - XM_006514448
RefSeq Peptide - NP_766026
swissprot - A0A0R4J0J6
swissprot - Q5SVF8
swissprot - Q5SVF9
Ensembl - ENSMUSG00000034274
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thoc5ENSDARG00000038290Danio rerio
 THOC5ENSGALG00000029223Gallus gallus
 THOC5ENSG00000100296Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019163  THO complex, subunit 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006406 mRNA export from nucleus IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0032786 positive regulation of DNA-templated transcription, elongation IEA
 biological_processGO:0046784 viral mRNA export from host cell nucleus IEA
 biological_processGO:2000002 negative regulation of DNA damage checkpoint IEA
 cellular_componentGO:0000346 transcription export complex IEA
 cellular_componentGO:0000347 THO complex IEA
 cellular_componentGO:0000445 THO complex part of transcription export complex IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA 3-end processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Nr1h2tm1.1Nph/Nr1h2tm1.1Nph
Genetic Background: B6.129-Nr1h2tm1.1Nph

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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