| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001354 | increased aggression towards males | "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9] |
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001360 | abnormal social investigation | "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001378 | abnormal ejaculation | "anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Arhgap1tm1Yizh/Arhgap1tm1Yizh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0001442 | decreased grooming behavior | "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001463 | abnormal spatial learning | "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University] |
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Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001473 | reduced long term potentiation | "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3] |
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0001900 | impaired synaptic plasticity | "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Ergtm2Poet/Ergtm2Poet
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0002229 | CNS neurodegeneration | "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * FVB/N
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| MP:0002797 | thigmotaxis | "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814] |
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0002912 | abnormal excitatory postsynaptic potential | "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Kcna2Pgu/Kcna2+
Genetic Background: involves: C3H/HeJ * C57BL/6J
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| MP:0003244 | loss of dopaminergic neurons | "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Grntm1Far/Grntm1Far,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
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| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J
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| MP:0003461 | abnormal response to novel object | "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University] |
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Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
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| MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J
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| MP:0003691 | abnormal microglial cell function | "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0003862 | decreased aggression towards males | "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
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| MP:0004022 | abnormal cone electrophysiology | "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0004811 | abnormal neuron physiology | "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Grntm1Far/Grntm1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0005165 | increased susceptibility to injury | "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0006303 | abnormal retinal nerve fiber layer morphology | "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0008056 | abnormal retinal ganglion cell morphology | "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0008067 | retinal ganglion cell degeneration | "degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm2Rev/Ppargtm2Rev,Tg(Tagln-cre)1Her/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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| MP:0008143 | abnormal dendrite morphology | "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
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| MP:0008415 | abnormal neurite morphology | "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572] |
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Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
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| MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0008657 | increased interleukin-1 beta secretion | "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0008660 | increased interleukin-10 secretion | "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0008663 | increased interleukin-12 secretion | "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0008722 | abnormal chemokine secretion | "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
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| MP:0008842 | lipofuscinosis | "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
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| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
Allelic Composition: Grntm1Far/Grntm1Far,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
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| MP:0008986 | abnormal liver parenchyma morphology | "any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J
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| MP:0009936 | abnormal dendritic spine morphology | "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J
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| MP:0010080 | abnormal hepatocyte physiology | "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011451 | increased susceptibility to dopaminergic neuron neurotoxicity | "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith] |
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Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
Allelic Composition: Grntm1Far/Grntm1Far,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
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| MP:0012143 | decreased a wave amplitude | "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith] |
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Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0012144 | decreased b wave amplitude | "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith] |
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Allelic Composition: Grntm1.1Far/Grntm1.1Far
Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N
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| MP:0020427 | increased hepatocyte karyomegaly | "an increase in the number or proportion of liver cells with enlarged nuclei" [PMID:22733568, PMID:26980189, PMID:7731963, PMID:8701981, url:http://medical-dictionary.thefreedictionary.com/karyomegaly] |
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Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J
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