ENSMUSG00000034829


Mus musculus

Features
Gene ID: ENSMUSG00000034829
  
Biological name :Nxnl1
  
Synonyms : Nucleoredoxin-like protein 1 / Nxnl1 / Q8VC33
  
Possible biological names infered from orthology : nucleoredoxin like 1 / Q96CM4
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B3.3
Gene start: 71560555
Gene end: 71566601
  
Corresponding Affymetrix probe sets: 10579543 (MoGene1.0st)   1425696_at (Mouse Genome 430 2.0 Array)   1426130_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039294
Ensembl peptide - ENSMUSP00000127094
NCBI entrez gene - 234404     See in Manteia.
MGI - MGI:1924446
RefSeq - NM_145598
RefSeq Peptide - NP_663573
swissprot - Q8VC33
Ensembl - ENSMUSG00000034829
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nxnl1ENSDARG00000052035Danio rerio
 NXNL1ENSG00000171773Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nxnl2 / Q9D531 / Nucleoredoxin-like protein 2 / Q5VZ03* / nucleoredoxin like 2*ENSMUSG0000002139627
Nxn / P97346 / Nucleoredoxin / Q6DKJ4*ENSMUSG0000002084422


Protein motifs (from Interpro)
Interpro ID Name
 IPR012336  Thioredoxin-like fold
 IPR029520  Nucleoredoxin-like protein 1
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045494 photoreceptor cell maintenance IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004791 thioredoxin-disulfide reductase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mdm2tm1Bay/Mdm2tm1Bay,Trp53tm2.1Kasa/Trp53tm2.1Kasa
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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