ENSMUSG00000034891


Mus musculus

Features
Gene ID: ENSMUSG00000034891
  
Biological name :Sncb
  
Synonyms : Beta-synuclein / Q91ZZ3 / Sncb
  
Possible biological names infered from orthology : Q16143 / synuclein beta
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 54758860
Gene end: 54766595
  
Corresponding Affymetrix probe sets: 10409369 (MoGene1.0st)   1418053_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043074
Ensembl peptide - ENSMUSP00000116296
NCBI entrez gene - 104069     See in Manteia.
MGI - MGI:1889011
RefSeq - XM_006517016
RefSeq - NM_033610
RefSeq - XM_006517015
RefSeq Peptide - NP_291088
swissprot - Q91ZZ3
Ensembl - ENSMUSG00000034891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sncbENSDARG00000104945Danio rerio
 SNCBENSGALG00000021542Gallus gallus
 SNCBENSG00000074317Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Snca / O55042 / Alpha-synuclein / P37840* / synuclein alpha*ENSMUSG0000002588964
Sncg / Q9Z0F7 / synuclein, gamma / O76070*ENSMUSG0000002306450


Protein motifs (from Interpro)
Interpro ID Name
 IPR001058  Synuclein
 IPR002461  Beta-synuclein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0042417 dopamine metabolic process IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0050808 synapse organization IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016234 inclusion body ISO
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0046914 transition metal ion binding ISO
 molecular_functionGO:1903136 cuprous ion binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lyntm1Mhi/Lyntm1Mhi
Genetic Background: involves: 129S1/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnajc5tm1Sud/Dnajc5tm1Sud,Sncatm1Sud/Sncatm1Sud,Sncbtm1.1Sud/Sncbtm1.1Sud
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0003795 abnormal bone structure 
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Zic4tm2Kjmi/Zic4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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