| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0000066 | osteoporosis | "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Eps8tm1Ppdf/Eps8tm1Ppdf,Eps8l2tm1Wma/Eps8l2tm1Wma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0000166 | abnormal chondrocyte morphology | "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0000447 | flattened snout | |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0000613 | abnormal salivary gland morphology | "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764] |
Show
Allelic Composition: Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam,Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
|
| MP:0000748 | progressive muscle weakness | "increasing loss of strength over time" [MGI:CLS, J:67994] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0000889 | abnormal cerebellar molecular layer | "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001169 | abnormal bulbourethral gland morphology | "malformed gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:54465, J:63764] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0001200 | thick skin | "greater depth of skin " [J:47225] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Eps8tm1Ppdf/Eps8tm1Ppdf,Eps8l2tm1Wma/Eps8l2tm1Wma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001541 | abnormal osteoclast function | "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001570 | abnormal circulating enzyme level | "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001847 | brain inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0001944 | abnormal pancreas morphology | "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Eps8tm1Ppdf/Eps8tm1Ppdf,Eps8l2tm1Wma/Eps8l2tm1Wma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0002161 | abnormal fertility/fecundity | "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0003172 | abnormal lysosome physiology | "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0003174 | increased lysosomal enzyme secretion | "production of glycoprotein hydrolytic enzymes is increased compared to normal" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0003354 | astrocytosis | "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0003652 | abnormal skin turgor | "anomaly in the ability of the skin to resist deformation; influential factors include dehydration and age" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0003728 | abnormal photoreceptor layer | "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0003743 | abnormal facial morphology | "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0003793 | abnormal submandibular gland morphology | "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0003797 | abnormal compact bone morphology | "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0003961 | decreased lean body mass | "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0004016 | decreased bone mass | "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0004097 | abnormal cerebellar cortex morphology | "any structural anomaly of the thin mantle of gray matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0004174 | abnormal spine curvature | "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0004704 | short vertebral column | "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0004984 | increased osteoclast cell number | "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0004986 | abnormal osteoblast morphology | "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0004992 | increased bone resorption | "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0005059 | lysosomal protein accumulation | "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0005220 | abnormal exocrine pancreas morphology | "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: Not Specified
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0006162 | thick eyelids | "increased width of the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0006395 | abnormal epiphyseal plate morphology | "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0008263 | abnormal hippocampus CA1 region morphology | |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0008267 | abnormal hippocampus CA3 region morphology | |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0008450 | retinal photoreceptor degeneration | "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0008705 | increased interleukin-6 secretion | "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
Show
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0008753 | abnormal osteocyte morphology | "any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi" [MESH:A.11.329.629.500] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
|
| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0009105 | penis prolapse | "inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0009146 | abnormal pancreatic acinar cell morphology | "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0009160 | abnormal pancreatic acinar cell zymogen granule | "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
|
| MP:0009978 | abnormal cerebellum white matter morphology | |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0010047 | axonal spheroids | "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421] |
Show
Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
|
| MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
|
| MP:0010879 | decreased trabecular bone volume | "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
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| MP:0011711 | decreased osteoblast differentiation | |
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Allelic Composition: Gnptabtm1Kkol/Gnptabtm1Kkol
Genetic Background: involves: 129 * C57BL/6
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| MP:0012506 | brain atrophy | "acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
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| MP:0013159 | Purkinje cell axonal dystrophy | "Purkinje cell-autonomous progressive dystrophy leading to cell death, manifested by axonal swellings and degeneration of nerve terminals, while Purkinje cell dendrites remain largely unaffected" [MGI:csmith] |
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Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
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| MP:0013558 | abnormal exocrine gland morphology | "any structural anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, MGI:Anna] |
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
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| MP:0013582 | abnormal lateral nasal gland morphology | "any structural anomaly of the lateral nasal glands (the largest nasal secretory glands in rodents) which surround the maxillary sinus located in the lateral wall adjacent to each nasal passage and are characterized by cytologic features similar to those described for the major serous salivary glands; secretory contents of the LNG drain into the nasal vestibule; the LNG is a major site for the synthesis and secretion of odorant-binding proteins that serve as odorant carriers in nasal mucus; it also, synthesizes large amounts of immunoglobulin A, which is important for immune defense of the upper respiratory tract, and testosterone and salivary androgen-binding proteins, which are likely important in olfaction and reproductive behavior" [ISBN:0080454321, ISBN:0123813611, MGI:Anna] |
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
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| MP:0013594 | abnormal parotid gland acinus morphology | "any structural anomaly of any of the secretory units (acini) of either parotid gland which in human and rodent consist almost exclusively of serous secretory cells with their lumina continuous with intercalated ducts; in mouse, parotid gland acini are very small and consist of 3-4 tall pyramidal cells with strongly basophilic cytoplasm and basally located, large spherical nuclei; the serous secretory cells contain many secretory granules having an electron-lucent profile which are situated in the supranuclear cytoplasm; the serous secretory cells have a well-developed rough endoplasmic reticulum in the infranuclear region and are surrounded by myoepithelial cells" [http://ctrgenpath.net/static/atlas/mousehistology/Windows/digestive/parotide.html, MGI:Anna, PMID:23209333] |
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
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| MP:0014114 | abnormal cognition | "any anomaly in the operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory" [GO:0050890] |
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Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
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| MP:0014185 | cerebellum atrophy | "acquired diminution of the size of the cerebellum associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna] |
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Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
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| MP:0030035 | small nasal bridge | "reduced size of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose; it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [MGI:anna] |
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Allelic Composition: Gnptabnym/Gnptabnym
Genetic Background: involves: BALB/cAnNHsd * C3H/HeNHsd
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| MP:0030074 | coarse facial features | "absence of fine and sharp appearance of facial features, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues" [HP:0000280] |
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6
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