ENSMUSG00000035357


Mus musculus

Features
Gene ID: ENSMUSG00000035357
  
Biological name :Pdzrn3
  
Synonyms : E3 ubiquitin-protein ligase PDZRN3 / Pdzrn3 / Q69ZS0
  
Possible biological names infered from orthology : PDZ domain containing ring finger 3 / Q9UPQ7
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 101149609
Gene end: 101377897
  
Corresponding Affymetrix probe sets: 10546725 (MoGene1.0st)   1416846_a_at (Mouse Genome 430 2.0 Array)   1443309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075376
NCBI entrez gene - 55983     See in Manteia.
MGI - MGI:1933157
RefSeq - NM_018884
RefSeq - XM_006506405
RefSeq Peptide - NP_061372
swissprot - Q69ZS0
Ensembl - ENSMUSG00000035357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7FDW2ENSDARG00000073869Danio rerio
 pdzrn3aENSDARG00000073757Danio rerio
 PDZRN3ENSGALG00000007819Gallus gallus
 PDZRN3ENSG00000121440Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdzrn4 / PDZ domain containing ring finger 4 / Q6ZMN7*ENSMUSG0000003621851
Pdzd4 / Q9QY39 / PDZ domain-containing protein 4 / Q76G19* / PDZ domain containing 4*ENSMUSG0000000200636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001478  PDZ domain
 IPR001841  Zinc finger, RING-type
 IPR008974  TRAF-like
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001711 abnormal placenta 
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001723 disorganized vascular plexus 
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/?,Pdzrn3tm1.1Saga/Pdzrn3tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

 MP:0010664 abnormal vitelline artery morphology "any structural anomaly of the paired arteries that carry blood to the yolk sac from the dorsal aorta; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Cnptm1(cre)Kan/Cnp+,Tfamtm1Lrsn/Tfamtm1Lrsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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