Manteia

ENSMUSG00000035493

Mus musculus

Features

Gene ID:	ENSMUSG00000035493

Biological name :	Tgfbi

Synonyms :	P82198 / Tgfbi / transforming growth factor, beta induced

Possible biological names infered from orthology :	Q15582

Species:	Mus musculus

Chr. number:	13
Strand:	1
Band:	B1
Gene start:	56609523
Gene end:	56639562

Corresponding Affymetrix probe sets:	10405587 (MoGene1.0st) 1415871_at (Mouse Genome 430 2.0 Array) 1437463_x_at (Mouse Genome 430 2.0 Array) 1448123_s_at (Mouse Genome 430 2.0 Array) 1456250_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000153546 Ensembl peptide - ENSMUSP00000037719 NCBI entrez gene - 21810 See in Manteia. MGI - MGI:99959 RefSeq - NM_009369 RefSeq Peptide - NP_033395 swissprot - A1L353 swissprot - P82198 swissprot - Q3UXJ2 Ensembl - ENSMUSG00000035493

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tgfbi	ENSDARG00000071586	Danio rerio
TGFBI	ENSGALG00000029429	Gallus gallus
TGFBI	ENSG00000120708	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Postn / Q62009 / periostin, osteoblast specific factor / Q15063* / periostin*	ENSMUSG00000027750	45

Protein motifs (from Interpro)

Interpro ID	Name
IPR000782	FAS1 domain
IPR011489	EMI domain
IPR016666	TGF beta-induced protein/periostin
IPR032954	Transforming growth factor-beta-induced protein ig-h3
IPR036378	FAS1 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001525	angiogenesis	IEA
biological_process	GO:0002062	chondrocyte differentiation	IEA
biological_process	GO:0007155	cell adhesion	IDA
biological_process	GO:0008283	cell proliferation	IEA
biological_process	GO:0030198	extracellular matrix organization	IDA
cellular_component	GO:0005576	extracellular region	ISO
cellular_component	GO:0005604	basement membrane	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005802	trans-Golgi network	ISO
cellular_component	GO:0031012	extracellular matrix	IEA
molecular_function	GO:0005178	integrin binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005518	collagen binding	ISO
molecular_function	GO:0050840	extracellular matrix binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0002018	malignant tumors	"higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0002027	lung adenocarcinoma	"malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0003059	decreased insulin secretion	"less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺ Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}
MP:0003111	abnormal nucleus morphology	"abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0003562	abnormal beta cell physiology	"anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺ Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}
MP:0003702	abnormal chromosome morphology	"anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0005215	abnormal islet of Langerhans morphology	"anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺ Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}
MP:0011996	abnormal retinal inner nuclear layer thickness	"anomaly in the thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:csmith]	Show Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre/Esr1)#Dam/0 Genetic Background:* involves: C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Gsk3b^tm1.1Atak/Gsk3b⁺ Genetic Background: involves: C57BL/6
MP:0014117	increased pancreatic beta cell apoptosis	"increase in the number of pancreatic beta cells undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺ Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}
MP:0020087	increased susceptibility to non-insulin-dependent diabetes	"increased likelihood to develop non-insulin-dependent diabetes" [GOC:NV]	Show Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺ Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}
MP:0030006	decreased retinal apoptosis	"decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Senp1^tm1.1Eyeh/Senp1^tm1.1Eyeh,Tg(Pdx1-cre/Esr1)#Dam/0 Genetic Background:* involves: C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr