ENSMUSG00000035764


Mus musculus

Features
Gene ID: ENSMUSG00000035764
  
Biological name :Fbxo45
  
Synonyms : F-box/SPRY domain-containing protein 1 / Fbxo45 / Q8K3B1
  
Possible biological names infered from orthology : F-box protein 45 / P0C2W1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 32230112
Gene end: 32247158
  
Corresponding Affymetrix probe sets: 10439063 (MoGene1.0st)   1428742_at (Mouse Genome 430 2.0 Array)   1452895_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040168
NCBI entrez gene - 268882     See in Manteia.
MGI - MGI:2447775
RefSeq - NM_173439
RefSeq Peptide - NP_775615
swissprot - Q8K3B1
Ensembl - ENSMUSG00000035764
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxo45ENSDARG00000071492Danio rerio
 FBXO45ENSGALG00000037281Gallus gallus
 FBXO45ENSG00000174013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spsb4 / Q8R5B6 / SPRY domain-containing SOCS box protein 4 / Q96A44* / splA/ryanodine receptor domain and SOCS box containing 4*ENSMUSG0000004699731
Spsb1 / Q9D5L7 / SPRY domain-containing SOCS box protein 1 / Q96BD6* / splA/ryanodine receptor domain and SOCS box containing 1*ENSMUSG0000003991128
Spsb2 / O88838 / SPRY domain-containing SOCS box protein 2 / Q99619* / splA/ryanodine receptor domain and SOCS box containing 2*ENSMUSG0000003845128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR035784  Fbxo45, SPRY domain
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021800 cerebral cortex tangential migration IMP
 biological_processGO:0021957 corticospinal tract morphogenesis IMP
 biological_processGO:0021960 anterior commissure morphogenesis IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0060384 innervation IMP
 biological_processGO:0060386 synapse assembly involved in innervation IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0000778 abnormal tract 
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0008503 abnormal spinal cord gray matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ednrbs-24Pub/Ednrbs-24Pub,m289-5Tpo/m289-5Tpo+
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL/6J * SSL/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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